A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation

The osteoblast differentiation capacity of skeletal stem cells (SSCs) must be tightly regulated, as inadequate bone formation results in low bone mass and skeletal fragility, and over-exuberant osteogenesis results in heterotopic ossification (HO) of soft tissues. RUNX2 is essential for tuning this...

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Detalles Bibliográficos
Autores principales: Kim, Jung-Min, Yang, Yeon-Suk, Park, Kwang Hwan, Ge, Xianpeng, Xu, Ren, Li, Na, Song, Minkyung, Chun, Hyunho, Bok, Seoyeon, Charles, Julia F., Filhol-Cochet, Odile, Boldyreff, Brigitte, Dinter, Teresa, Yu, Paul B., Kon, Ning, Gu, Wei, Takarada, Takeshi, Greenblatt, Matthew B., Shim, Jae-Hyuck
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210266/
https://www.ncbi.nlm.nih.gov/pubmed/32385263
http://dx.doi.org/10.1038/s41467-020-16038-6

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