Plasma membrane damage causes NLRP3 activation and pyroptosis during Mycobacterium tuberculosis infection

Mycobacterium tuberculosis is a global health problem in part as a result of extensive cytotoxicity caused by the infection. Here, we show how M. tuberculosis causes caspase-1/NLRP3/gasdermin D-mediated pyroptosis of human monocytes and macrophages. A type VII secretion system (ESX-1) mediated, cont...

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Detalles Bibliográficos
Autores principales: Beckwith, Kai S., Beckwith, Marianne S., Ullmann, Sindre, Sætra, Ragnhild S., Kim, Haelin, Marstad, Anne, Åsberg, Signe E., Strand, Trine A., Haug, Markus, Niederweis, Michael, Stenmark, Harald A., Flo, Trude H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210277/
https://www.ncbi.nlm.nih.gov/pubmed/32385301
http://dx.doi.org/10.1038/s41467-020-16143-6

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