Skin Delivery of siRNA Using Sponge Spicules in Combination with Cationic Flexible Liposomes

We report the topical administration of sponge Haliclona sp. Spicules (SHS) combined with cationic flexible liposomes (CFL) to increase the delivery of small interfering RNA (siRNA) into viable skin cells in vitro and in vivo. SHS can be applied topically as novel microneedles to overcome skin barri...

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Detalles Bibliográficos
Autores principales: Liang, XueJiao, Zhang, JiaLiang, Ou, HuiLong, Chen, Jun, Mitragotri, Samir, Chen, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210381/
https://www.ncbi.nlm.nih.gov/pubmed/32380414
http://dx.doi.org/10.1016/j.omtn.2020.04.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210381/
https://www.ncbi.nlm.nih.gov/pubmed/32380414
http://dx.doi.org/10.1016/j.omtn.2020.04.003

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