Age-related increase of kynurenine enhances miR29b-1-5p to decrease both CXCL12 signaling and the epigenetic enzyme Hdac3 in bone marrow stromal cells

Mechanisms leading to age-related reductions in bone formation and subsequent osteoporosis are still incompletely understood. We recently demonstrated that kynurenine (KYN), a tryptophan metabolite, accumulates in serum of aged mice and induces bone loss. Here, we report on novel mechanisms underlyi...

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Detalles Bibliográficos
Autores principales: Elmansi, Ahmed M., Hussein, Khaled A., Herrero, Sergio Mas, Periyasamy-Thandavan, Sudharsan, Aguilar-Pérez, Alexandra, Kondrikova, Galina, Kondrikov, Dmitry, Eisa, Nada H., Pierce, Jessica L., Kaiser, Helen, Ding, Ke-Hong, Walker, Aisha L., Jiang, Xue, Bollag, Wendy B., Elsalanty, Mohammed, Zhong, Qing, Shi, Xing-ming, Su, Yun, Johnson, Maribeth, Hunter, Monte, Reitman, Charles, Volkman, Brian F., Hamrick, Mark W., Isales, Carlos M., Fulzele, Sadanand, McGee-Lawrence, Meghan E., Hill, William D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210406/
https://www.ncbi.nlm.nih.gov/pubmed/32395570
http://dx.doi.org/10.1016/j.bonr.2020.100270

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210406/
https://www.ncbi.nlm.nih.gov/pubmed/32395570
http://dx.doi.org/10.1016/j.bonr.2020.100270

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