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Mir-30b-5p Promotes Proliferation, Migration, and Invasion of Breast Cancer Cells via Targeting ASPP2

Triple-negative breast cancer (TNBC) is the most aggressive subtypes of breast cancer, which has few effective targeted therapies. Various sources of evidence confirm that microRNAs (miRNAs) contribute to the progression and metastasis of human breast cancer. However, the molecular mechanisms underl...

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Detalles Bibliográficos
Autores principales: Wu, Tianqi, Song, Hongming, Xie, Dan, Hua, Kaiyao, Hu, Jiashu, Deng, Yijun, Ji, Changle, Fang, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210518/
https://www.ncbi.nlm.nih.gov/pubmed/32420372
http://dx.doi.org/10.1155/2020/7907269
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author Wu, Tianqi
Song, Hongming
Xie, Dan
Hua, Kaiyao
Hu, Jiashu
Deng, Yijun
Ji, Changle
Fang, Lin
author_facet Wu, Tianqi
Song, Hongming
Xie, Dan
Hua, Kaiyao
Hu, Jiashu
Deng, Yijun
Ji, Changle
Fang, Lin
author_sort Wu, Tianqi
collection PubMed
description Triple-negative breast cancer (TNBC) is the most aggressive subtypes of breast cancer, which has few effective targeted therapies. Various sources of evidence confirm that microRNAs (miRNAs) contribute to the progression and metastasis of human breast cancer. However, the molecular mechanisms underlying the changes in miRNAs expression and the regulation of miRNAs functions have not been well clarified. In this study, we found that the expression of miR-30b-5p was upregulated in breast cancer tissues and breast cancer cell lines, compared to paracancer tissues and normal breast cell lines. Moreover, induced overexpression of miR-30b-5p promoted the MDA-MB-231 and HCC 1937 cell growth, migration, and invasion and reduced the cellular apoptosis. Further studies confirmed that miR-30b-5p could directly target ASPP2 and then activate the AKT signaling pathway. Our results suggested that miR-30b-5p could act as a tumor promoter in TNBC. The newly identified miR-30b-5p/ASPP2/AKT axis represents a novel therapeutic strategy for treating TNBC.
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spelling pubmed-72105182020-05-15 Mir-30b-5p Promotes Proliferation, Migration, and Invasion of Breast Cancer Cells via Targeting ASPP2 Wu, Tianqi Song, Hongming Xie, Dan Hua, Kaiyao Hu, Jiashu Deng, Yijun Ji, Changle Fang, Lin Biomed Res Int Research Article Triple-negative breast cancer (TNBC) is the most aggressive subtypes of breast cancer, which has few effective targeted therapies. Various sources of evidence confirm that microRNAs (miRNAs) contribute to the progression and metastasis of human breast cancer. However, the molecular mechanisms underlying the changes in miRNAs expression and the regulation of miRNAs functions have not been well clarified. In this study, we found that the expression of miR-30b-5p was upregulated in breast cancer tissues and breast cancer cell lines, compared to paracancer tissues and normal breast cell lines. Moreover, induced overexpression of miR-30b-5p promoted the MDA-MB-231 and HCC 1937 cell growth, migration, and invasion and reduced the cellular apoptosis. Further studies confirmed that miR-30b-5p could directly target ASPP2 and then activate the AKT signaling pathway. Our results suggested that miR-30b-5p could act as a tumor promoter in TNBC. The newly identified miR-30b-5p/ASPP2/AKT axis represents a novel therapeutic strategy for treating TNBC. Hindawi 2020-04-29 /pmc/articles/PMC7210518/ /pubmed/32420372 http://dx.doi.org/10.1155/2020/7907269 Text en Copyright © 2020 Tianqi Wu et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Wu, Tianqi
Song, Hongming
Xie, Dan
Hua, Kaiyao
Hu, Jiashu
Deng, Yijun
Ji, Changle
Fang, Lin
Mir-30b-5p Promotes Proliferation, Migration, and Invasion of Breast Cancer Cells via Targeting ASPP2
title Mir-30b-5p Promotes Proliferation, Migration, and Invasion of Breast Cancer Cells via Targeting ASPP2
title_full Mir-30b-5p Promotes Proliferation, Migration, and Invasion of Breast Cancer Cells via Targeting ASPP2
title_fullStr Mir-30b-5p Promotes Proliferation, Migration, and Invasion of Breast Cancer Cells via Targeting ASPP2
title_full_unstemmed Mir-30b-5p Promotes Proliferation, Migration, and Invasion of Breast Cancer Cells via Targeting ASPP2
title_short Mir-30b-5p Promotes Proliferation, Migration, and Invasion of Breast Cancer Cells via Targeting ASPP2
title_sort mir-30b-5p promotes proliferation, migration, and invasion of breast cancer cells via targeting aspp2
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210518/
https://www.ncbi.nlm.nih.gov/pubmed/32420372
http://dx.doi.org/10.1155/2020/7907269
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