Cargando…

Kinetic estimation of solid state transition during isothermal and grinding processes among efavirenz polymorphs

Investigation into the solid-state transition among drug polymorphs has been more intense lately. Many factors induce the transformation of polymorphs during manufacturing processes. Efavirenz (EFV), an AIDS therapy drug, has more than 23 polymorphs, but very little information has been reported on...

Descripción completa

Detalles Bibliográficos
Autores principales: Wardhana, Yoga Windhu, Hardian, Arie, Chaerunisa, Anis Y., Suendo, Veinardi, Soewandhi, Sundani N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210586/
https://www.ncbi.nlm.nih.gov/pubmed/32405549
http://dx.doi.org/10.1016/j.heliyon.2020.e03876
_version_ 1783531304328888320
author Wardhana, Yoga Windhu
Hardian, Arie
Chaerunisa, Anis Y.
Suendo, Veinardi
Soewandhi, Sundani N.
author_facet Wardhana, Yoga Windhu
Hardian, Arie
Chaerunisa, Anis Y.
Suendo, Veinardi
Soewandhi, Sundani N.
author_sort Wardhana, Yoga Windhu
collection PubMed
description Investigation into the solid-state transition among drug polymorphs has been more intense lately. Many factors induce the transformation of polymorphs during manufacturing processes. Efavirenz (EFV), an AIDS therapy drug, has more than 23 polymorphs, but very little information has been reported on them. This study aimed to perform a characterisation of EFV polymorph properties and to predict the kinetics and mechanism of the polymorphic transformation of EFV during manufacturing processes. The bimorphism study was conducted by Differential Scanning Calorimetry (DSC) thermal analysis. The phase transition kinetics of the polymorphs was monitored by X-ray powder diffraction and the quantification of concomitant polymorphs was examined using Rietveld refinement with MAUD ver. 2.7 as a software aid. To predict the solid-state transition, correlation coefficients of solid-state kinetic models were fitted to the experimental data. The results show that Form I and Form II of EFV were thermodynamically shown to be monotropy related. By fitting the experimental data, it was found that isothermal treatment had the best model fit with the phase boundary reaction in the two-dimensional model (G2). Accordingly, by employing mechanical treatment (grinding), it was predicted that the transition mechanism is a second-ordered reaction (R2). The activation energy of the transition during isothermal treatment calculated by the Arrhenius plot was found to be 23.051 kJ mol(−1); the half-lif of Form II at ambient temperature was 428.05 min (~7.1 h).
format Online
Article
Text
id pubmed-7210586
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-72105862020-05-13 Kinetic estimation of solid state transition during isothermal and grinding processes among efavirenz polymorphs Wardhana, Yoga Windhu Hardian, Arie Chaerunisa, Anis Y. Suendo, Veinardi Soewandhi, Sundani N. Heliyon Article Investigation into the solid-state transition among drug polymorphs has been more intense lately. Many factors induce the transformation of polymorphs during manufacturing processes. Efavirenz (EFV), an AIDS therapy drug, has more than 23 polymorphs, but very little information has been reported on them. This study aimed to perform a characterisation of EFV polymorph properties and to predict the kinetics and mechanism of the polymorphic transformation of EFV during manufacturing processes. The bimorphism study was conducted by Differential Scanning Calorimetry (DSC) thermal analysis. The phase transition kinetics of the polymorphs was monitored by X-ray powder diffraction and the quantification of concomitant polymorphs was examined using Rietveld refinement with MAUD ver. 2.7 as a software aid. To predict the solid-state transition, correlation coefficients of solid-state kinetic models were fitted to the experimental data. The results show that Form I and Form II of EFV were thermodynamically shown to be monotropy related. By fitting the experimental data, it was found that isothermal treatment had the best model fit with the phase boundary reaction in the two-dimensional model (G2). Accordingly, by employing mechanical treatment (grinding), it was predicted that the transition mechanism is a second-ordered reaction (R2). The activation energy of the transition during isothermal treatment calculated by the Arrhenius plot was found to be 23.051 kJ mol(−1); the half-lif of Form II at ambient temperature was 428.05 min (~7.1 h). Elsevier 2020-05-05 /pmc/articles/PMC7210586/ /pubmed/32405549 http://dx.doi.org/10.1016/j.heliyon.2020.e03876 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Wardhana, Yoga Windhu
Hardian, Arie
Chaerunisa, Anis Y.
Suendo, Veinardi
Soewandhi, Sundani N.
Kinetic estimation of solid state transition during isothermal and grinding processes among efavirenz polymorphs
title Kinetic estimation of solid state transition during isothermal and grinding processes among efavirenz polymorphs
title_full Kinetic estimation of solid state transition during isothermal and grinding processes among efavirenz polymorphs
title_fullStr Kinetic estimation of solid state transition during isothermal and grinding processes among efavirenz polymorphs
title_full_unstemmed Kinetic estimation of solid state transition during isothermal and grinding processes among efavirenz polymorphs
title_short Kinetic estimation of solid state transition during isothermal and grinding processes among efavirenz polymorphs
title_sort kinetic estimation of solid state transition during isothermal and grinding processes among efavirenz polymorphs
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210586/
https://www.ncbi.nlm.nih.gov/pubmed/32405549
http://dx.doi.org/10.1016/j.heliyon.2020.e03876
work_keys_str_mv AT wardhanayogawindhu kineticestimationofsolidstatetransitionduringisothermalandgrindingprocessesamongefavirenzpolymorphs
AT hardianarie kineticestimationofsolidstatetransitionduringisothermalandgrindingprocessesamongefavirenzpolymorphs
AT chaerunisaanisy kineticestimationofsolidstatetransitionduringisothermalandgrindingprocessesamongefavirenzpolymorphs
AT suendoveinardi kineticestimationofsolidstatetransitionduringisothermalandgrindingprocessesamongefavirenzpolymorphs
AT soewandhisundanin kineticestimationofsolidstatetransitionduringisothermalandgrindingprocessesamongefavirenzpolymorphs