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BRCA testing in a genomic diagnostics referral center during the COVID-19 pandemic
The first person-to-person transmission of the 2019-novel coronavirus in Italy on 21 February 2020 led to an infection chain that represents one of the largest known COVID-19 outbreaks outside Asia. Hospitals have been forced to reorganized their units in response to prepare for an unforeseen health...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Netherlands
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210797/ https://www.ncbi.nlm.nih.gov/pubmed/32388698 http://dx.doi.org/10.1007/s11033-020-05479-3 |
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author | Minucci, Angelo Scambia, Giovanni Santonocito, Concetta Concolino, Paola Urbani, Andrea |
author_facet | Minucci, Angelo Scambia, Giovanni Santonocito, Concetta Concolino, Paola Urbani, Andrea |
author_sort | Minucci, Angelo |
collection | PubMed |
description | The first person-to-person transmission of the 2019-novel coronavirus in Italy on 21 February 2020 led to an infection chain that represents one of the largest known COVID-19 outbreaks outside Asia. Hospitals have been forced to reorganized their units in response to prepare for an unforeseen healthcare emergency. In this context, our laboratory (Molecular and Genomic Diagnostics Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS) re-modulated its priorities by temporarily interrupting most of the molecular tests guaranteeing only those considered “urgent” and not postponable. In particular, this paper details changes regarding the execution of germline BRCA (gBRCA) testing in our laboratory. A substantial reduction in gBRCA testing (about 60%) compared to the first 2 months of the current year was registered, but the requests have not been reset. The requesting physicians were mainly gynaecologists and oncologists. These evidences further emphasize the new era of gBRCA testing in the management of cancer patients and confirms definitively the integration of gBRCA testing/Next Generation Sequencing (NGS) into clinical oncology. Finally, a re-organization of gBRCA testing in our Unit, mainly related to delayed and reduced arrival of tests was necessary, ensuring, however, a high-quality standard and reliability, mandatory for gBRCA testing in a clinical setting. |
format | Online Article Text |
id | pubmed-7210797 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer Netherlands |
record_format | MEDLINE/PubMed |
spelling | pubmed-72107972020-05-11 BRCA testing in a genomic diagnostics referral center during the COVID-19 pandemic Minucci, Angelo Scambia, Giovanni Santonocito, Concetta Concolino, Paola Urbani, Andrea Mol Biol Rep Short Communication The first person-to-person transmission of the 2019-novel coronavirus in Italy on 21 February 2020 led to an infection chain that represents one of the largest known COVID-19 outbreaks outside Asia. Hospitals have been forced to reorganized their units in response to prepare for an unforeseen healthcare emergency. In this context, our laboratory (Molecular and Genomic Diagnostics Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS) re-modulated its priorities by temporarily interrupting most of the molecular tests guaranteeing only those considered “urgent” and not postponable. In particular, this paper details changes regarding the execution of germline BRCA (gBRCA) testing in our laboratory. A substantial reduction in gBRCA testing (about 60%) compared to the first 2 months of the current year was registered, but the requests have not been reset. The requesting physicians were mainly gynaecologists and oncologists. These evidences further emphasize the new era of gBRCA testing in the management of cancer patients and confirms definitively the integration of gBRCA testing/Next Generation Sequencing (NGS) into clinical oncology. Finally, a re-organization of gBRCA testing in our Unit, mainly related to delayed and reduced arrival of tests was necessary, ensuring, however, a high-quality standard and reliability, mandatory for gBRCA testing in a clinical setting. Springer Netherlands 2020-05-09 2020 /pmc/articles/PMC7210797/ /pubmed/32388698 http://dx.doi.org/10.1007/s11033-020-05479-3 Text en © Springer Nature B.V. 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Short Communication Minucci, Angelo Scambia, Giovanni Santonocito, Concetta Concolino, Paola Urbani, Andrea BRCA testing in a genomic diagnostics referral center during the COVID-19 pandemic |
title | BRCA testing in a genomic diagnostics referral center during the COVID-19 pandemic |
title_full | BRCA testing in a genomic diagnostics referral center during the COVID-19 pandemic |
title_fullStr | BRCA testing in a genomic diagnostics referral center during the COVID-19 pandemic |
title_full_unstemmed | BRCA testing in a genomic diagnostics referral center during the COVID-19 pandemic |
title_short | BRCA testing in a genomic diagnostics referral center during the COVID-19 pandemic |
title_sort | brca testing in a genomic diagnostics referral center during the covid-19 pandemic |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210797/ https://www.ncbi.nlm.nih.gov/pubmed/32388698 http://dx.doi.org/10.1007/s11033-020-05479-3 |
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