Recurrent unintentional filtering blebs after vitrectomy: A case report

A lady who underwent lensectomy for microspherophakia and pars plana vitrectomy for retinal detachment in her left eye developed recurrent filtering blebs at the site of sclerotomies. Filtering blebs were managed by suturing the sclerotomies. Targeted gene sequencing identified a variant of ASPH gen...

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Autores principales: Shanmugam, P Mahesh, Sagar, Pradeep, Konana, Vinaya K, Simakurthy, Sriram, Ramanjulu, Rajesh, Sheemar, Abhishek, KC, Divyansh Mishra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210861/
https://www.ncbi.nlm.nih.gov/pubmed/32174599
http://dx.doi.org/10.4103/ijo.IJO_1249_19
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author Shanmugam, P Mahesh
Sagar, Pradeep
Konana, Vinaya K
Simakurthy, Sriram
Ramanjulu, Rajesh
Sheemar, Abhishek
KC, Divyansh Mishra
author_facet Shanmugam, P Mahesh
Sagar, Pradeep
Konana, Vinaya K
Simakurthy, Sriram
Ramanjulu, Rajesh
Sheemar, Abhishek
KC, Divyansh Mishra
author_sort Shanmugam, P Mahesh
collection PubMed
description A lady who underwent lensectomy for microspherophakia and pars plana vitrectomy for retinal detachment in her left eye developed recurrent filtering blebs at the site of sclerotomies. Filtering blebs were managed by suturing the sclerotomies. Targeted gene sequencing identified a variant of ASPH gene (p.Arg688Gln) which is not known to be associated with Traboulsi syndrome. But considering the paucity of cases with genetic analysis, it would be possible that p.Arg688Gln is a pathogenic variant. This is the first case report of Traboulsi syndrome due to an ASPH variant not reported earlier that can lead to recurrent filtering blebs.
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spelling pubmed-72108612020-05-12 Recurrent unintentional filtering blebs after vitrectomy: A case report Shanmugam, P Mahesh Sagar, Pradeep Konana, Vinaya K Simakurthy, Sriram Ramanjulu, Rajesh Sheemar, Abhishek KC, Divyansh Mishra Indian J Ophthalmol Case Reports A lady who underwent lensectomy for microspherophakia and pars plana vitrectomy for retinal detachment in her left eye developed recurrent filtering blebs at the site of sclerotomies. Filtering blebs were managed by suturing the sclerotomies. Targeted gene sequencing identified a variant of ASPH gene (p.Arg688Gln) which is not known to be associated with Traboulsi syndrome. But considering the paucity of cases with genetic analysis, it would be possible that p.Arg688Gln is a pathogenic variant. This is the first case report of Traboulsi syndrome due to an ASPH variant not reported earlier that can lead to recurrent filtering blebs. Wolters Kluwer - Medknow 2020-04 2020-03-16 /pmc/articles/PMC7210861/ /pubmed/32174599 http://dx.doi.org/10.4103/ijo.IJO_1249_19 Text en Copyright: © 2020 Indian Journal of Ophthalmology http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Case Reports
Shanmugam, P Mahesh
Sagar, Pradeep
Konana, Vinaya K
Simakurthy, Sriram
Ramanjulu, Rajesh
Sheemar, Abhishek
KC, Divyansh Mishra
Recurrent unintentional filtering blebs after vitrectomy: A case report
title Recurrent unintentional filtering blebs after vitrectomy: A case report
title_full Recurrent unintentional filtering blebs after vitrectomy: A case report
title_fullStr Recurrent unintentional filtering blebs after vitrectomy: A case report
title_full_unstemmed Recurrent unintentional filtering blebs after vitrectomy: A case report
title_short Recurrent unintentional filtering blebs after vitrectomy: A case report
title_sort recurrent unintentional filtering blebs after vitrectomy: a case report
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210861/
https://www.ncbi.nlm.nih.gov/pubmed/32174599
http://dx.doi.org/10.4103/ijo.IJO_1249_19
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