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Minimal lactazole scaffold for in vitro thiopeptide bioengineering

Lactazole A is a cryptic thiopeptide from Streptomyces lactacystinaeus, encoded by a compact 9.8 kb biosynthetic gene cluster. Here, we establish a platform for in vitro biosynthesis of lactazole A, referred to as the FIT-Laz system, via a combination of the flexible in vitro translation (FIT) syste...

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Detalles Bibliográficos
Autores principales:	Vinogradov, Alexander A., Shimomura, Morito, Goto, Yuki, Ozaki, Taro, Asamizu, Shumpei, Sugai, Yoshinori, Suga, Hiroaki, Onaka, Hiroyasu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210931/ https://www.ncbi.nlm.nih.gov/pubmed/32385237 http://dx.doi.org/10.1038/s41467-020-16145-4

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