Cargando…

Aberrant expression of the COX2/PGE(2) axis is induced by activation of the RAF/MEK/ERK pathway in BRAF(V595E) canine urothelial carcinoma

Cancer-promoting inflammation is an important event in cancer development. Canine urothelial carcinoma (cUC) overexpresses prostaglandin E(2) (PGE(2)) and has a unique sensitivity to cyclooxygenase 2 (COX2)-inhibiting therapy. In addition, majority of cUC harbour BRAF(V595E) mutation. However, mecha...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yoshitake, Ryohei, Saeki, Kohei, Eto, Shotaro, Shinada, Masahiro, Nakano, Rei, Sugiya, Hiroshi, Endo, Yoshifumi, Fujita, Naoki, Nishimura, Ryohei, Nakagawa, Takayuki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210937/ https://www.ncbi.nlm.nih.gov/pubmed/32385388 http://dx.doi.org/10.1038/s41598-020-64832-5

Ejemplares similares

Author Correction: Aberrant expression of the COX2/PGE(2) axis is induced by activation of the RAF/MEK/ERK pathway in BRAF(V595E) canine urothelial carcinoma
por: Yoshitake, Ryohei, et al.
Publicado: (2020)

Anti-tumor effects of the histone deacetylase inhibitor vorinostat on canine urothelial carcinoma cells
por: Eto, Shotaro, et al.
Publicado: (2019)

Immunohistochemical evaluation of HER2 expression in canine thyroid carcinoma
por: Yoshimoto, Sho, et al.
Publicado: (2019)

BRAF Mutations and the Utility of RAF and MEK Inhibitors in Primary Brain Tumors
por: Schreck, Karisa C., et al.
Publicado: (2019)

Detection of human epidermal growth factor receptor 2 overexpression in canine anal sac gland carcinoma
por: YOSHIMOTO, Sho, et al.
Publicado: (2019)

Establishment and characterization of urothelial carcinoma cell lines with and without BRAF mutation (V595E) in dogs
por: Yamasaki, Hirofumi, et al.
Publicado: (2022)

Artificial Intelligence to Predict the BRAF V595E Mutation in Canine Urinary Bladder Urothelial Carcinomas
por: Küchler, Leonore, et al.
Publicado: (2023)

Overexpression of human epidermal growth factor receptor 2 in canine primary lung cancer
por: YOSHIMOTO, Sho, et al.
Publicado: (2020)

Quantitative analysis of the BRAF V595E mutation in plasma cell-free DNA from dogs with urothelial carcinoma
por: Tagawa, Michihito, et al.
Publicado: (2020)

JNK activation is essential for activation of MEK/ERK signaling in IL-1β-induced COX-2 expression in synovial fibroblasts
por: Kitanaka, Taku, et al.
Publicado: (2017)

Detection of indoleamine 2,3-dioxygenase 1-expressing cells in canine normal and tumor tissues
por: IKEDA, Namiko, et al.
Publicado: (2021)

Rare BRAF mutations in pancreatic neuroendocrine tumors may predict response to RAF and MEK inhibition
por: Allen, Amy, et al.
Publicado: (2019)

PDPN Is Expressed in Various Types of Canine Tumors and Its Silencing Induces Apoptosis and Cell Cycle Arrest in Canine Malignant Melanoma
por: Shinada, Masahiro, et al.
Publicado: (2020)

Pan-RAF and MEK vertical inhibition enhances therapeutic response in non-V600 BRAF mutant cells
por: Molnár, Eszter, et al.
Publicado: (2018)

“RAF” neighborhood: Protein–protein interaction in the Raf/Mek/Erk pathway
por: Cseh, Botond, et al.
Publicado: (2014)

BRAF V600E-mutated metastatic pediatric Wilms tumor with complete response to targeted RAF/MEK inhibition
por: Obasaju, Patience, et al.
Publicado: (2020)

Phase I/II Clinical Trial of the Anti-Podoplanin Monoclonal Antibody Therapy in Dogs with Malignant Melanoma
por: Kamoto, Satoshi, et al.
Publicado: (2020)

Expression of podoplanin in various types of feline tumor tissues
por: KAMOTO, Satoshi, et al.
Publicado: (2021)

ErbB2 signaling epigenetically suppresses microRNA‐205 transcription via Ras/Raf/MEK/ERK pathway in breast cancer
por: Hasegawa, Takuya, et al.
Publicado: (2017)

Mixed lineage kinases activate MEK independently of RAF to mediate resistance to RAF inhibitors
por: Marusiak, Anna A., et al.
Publicado: (2014)

COX-2-PGE(2)-EPs in gynecological cancers
por: Ye, Yao, et al.
Publicado: (2020)

Conferring specificity on the ubiquitous Raf/MEK signalling pathway
por: O'Neill, E, et al.
Publicado: (2004)

Growth Inhibitory Signaling of the Raf/MEK/ERK Pathway
por: Wu, Pui-Kei, et al.
Publicado: (2020)

Whole exome sequencing analysis of canine urothelial carcinomas without BRAF V595E mutation: Short in-frame deletions in BRAF and MAP2K1 suggest alternative mechanisms for MAPK pathway disruption
por: Thomas, Rachael, et al.
Publicado: (2023)

RAF inhibitors transactivate RAF dimers and ERK signaling in cells with wild-type BRAF
por: Poulikakos, Poulikos I., et al.
Publicado: (2010)

Combination of pan-RAF and MEK inhibitors in NRAS mutant melanoma
por: Atefi, Mohammad, et al.
Publicado: (2015)

The mechanism of activation of MEK1 by B-Raf and KSR1
por: Maloney, Ryan C., et al.
Publicado: (2022)

The impact of damage-associated molecules released from canine tumor cells on gene expression in macrophages
por: Eto, Shotaro, et al.
Publicado: (2021)

Inhibition of BRAF and BRAF+MEK drives a metastatic switch in melanoma
por: Smalley, Keiran SM, et al.
Publicado: (2015)

Medical debulking with BRAF/MEK inhibitors in aggressive BRAF-mutant craniopharyngioma
por: Di Stefano, Anna Luisa, et al.
Publicado: (2020)

PDCD6 cooperates with C-Raf to facilitate colorectal cancer progression via Raf/MEK/ERK activation
por: Wang, Xiaojuan, et al.
Publicado: (2020)

PLX8394, a RAF inhibitor, inhibits enterovirus 71 replication by blocking RAF/MEK/ERK signaling
por: Wu, Chengyuan, et al.
Publicado: (2023)

Polymorphisms in RAS/RAF/MEK/ERK Pathway Are Associated with Gastric Cancer
por: Gonzalez-Hormazabal, Patricio, et al.
Publicado: (2018)

Targeting Aberrant RAS/RAF/MEK/ERK Signaling for Cancer Therapy
por: Degirmenci, Ufuk, et al.
Publicado: (2020)

Licochalcone A, a Polyphenol Present in Licorice, Suppresses UV-Induced COX-2 Expression by Targeting PI3K, MEK1, and B-Raf
por: Song, Nu Ry, et al.
Publicado: (2015)

Interactome dynamics of RAF1-BRAF kinase monomers and dimers
por: Iglesias-Martinez, Luis F., et al.
Publicado: (2023)

Regulated Expression of PTPRJ by COX-2/PGE(2) Axis in Endothelial Cells
por: Xu, Xiaobing, et al.
Publicado: (2014)

Pleiotropic effects of the COX-2/PGE2 axis in the glioblastoma tumor microenvironment
por: Dean, Phillip T., et al.
Publicado: (2023)

Global view of the RAF-MEK-ERK module and its immediate downstream effectors
por: Santini, Cristina C., et al.
Publicado: (2019)

Porcine deltacoronavirus activates the Raf/MEK/ERK pathway to promote its replication
por: Jeon, Ji Hyun, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_vsn1ihpkk21v3brs09fcq2tgu7