Flexibility of intrinsically disordered degrons in AUX/IAA proteins reinforces auxin co-receptor assemblies

Cullin RING-type E3 ubiquitin ligases SCF(TIR1/AFB1-5) and their AUX/IAA targets perceive the phytohormone auxin. The F-box protein TIR1 binds a surface-exposed degron in AUX/IAAs promoting their ubiquitylation and rapid auxin-regulated proteasomal degradation. Here, by adopting biochemical, structu...

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Detalles Bibliográficos
Autores principales: Niemeyer, Michael, Moreno Castillo, Elena, Ihling, Christian H., Iacobucci, Claudio, Wilde, Verona, Hellmuth, Antje, Hoehenwarter, Wolfgang, Samodelov, Sophia L., Zurbriggen, Matias D., Kastritis, Panagiotis L., Sinz, Andrea, Calderón Villalobos, Luz Irina A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210949/
https://www.ncbi.nlm.nih.gov/pubmed/32385295
http://dx.doi.org/10.1038/s41467-020-16147-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210949/
https://www.ncbi.nlm.nih.gov/pubmed/32385295
http://dx.doi.org/10.1038/s41467-020-16147-2

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