Spider venom-derived peptide induces hyperalgesia in Na(v)1.7 knockout mice by activating Na(v)1.9 channels

The sodium channels Na(v)1.7, Na(v)1.8 and Na(v)1.9 are critical for pain perception in peripheral nociceptors. Loss of function of Na(v)1.7 leads to congenital insensitivity to pain in humans. Here we show that the spider peptide toxin called HpTx1, first identified as an inhibitor of K(v)4.2, rest...

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Detalles Bibliográficos
Autores principales: Zhou, Xi, Ma, Tingbin, Yang, Luyao, Peng, Shuijiao, Li, Lulu, Wang, Zhouquan, Xiao, Zhen, Zhang, Qingfeng, Wang, Li, Huang, Yazhou, Chen, Minzhi, Liang, Songping, Zhang, Xianwei, Liu, Jing Yu, Liu, Zhonghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210961/
https://www.ncbi.nlm.nih.gov/pubmed/32385249
http://dx.doi.org/10.1038/s41467-020-16210-y

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