Phagosomal removal of fungal melanin reprograms macrophage metabolism to promote antifungal immunity

In response to infection, macrophages adapt their metabolism rapidly to enhance glycolysis and fuel specialized antimicrobial effector functions. Here we show that fungal melanin is an essential molecule required for the metabolic rewiring of macrophages during infection with the fungal pathogen Asp...

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Detalles Bibliográficos
Autores principales: Gonçalves, Samuel M., Duarte-Oliveira, Cláudio, Campos, Cláudia F., Aimanianda, Vishukumar, ter Horst, Rob, Leite, Luis, Mercier, Toine, Pereira, Paulo, Fernández-García, Miguel, Antunes, Daniela, Rodrigues, Cláudia S., Barbosa-Matos, Catarina, Gaifem, Joana, Mesquita, Inês, Marques, António, Osório, Nuno S., Torrado, Egídio, Rodrigues, Fernando, Costa, Sandra, Joosten, Leo AB., Lagrou, Katrien, Maertens, Johan, Lacerda, João F., Campos, António, Brown, Gordon D., Brakhage, Axel A., Barbas, Coral, Silvestre, Ricardo, van de Veerdonk, Frank L., Chamilos, Georgios, Netea, Mihai G., Latgé, Jean-Paul, Cunha, Cristina, Carvalho, Agostinho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210971/
https://www.ncbi.nlm.nih.gov/pubmed/32385235
http://dx.doi.org/10.1038/s41467-020-16120-z

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