Pemafibrate, a selective PPARα modulator, prevents non-alcoholic steatohepatitis development without reducing the hepatic triglyceride content

Non-alcoholic steatohepatitis (NASH) is characterized by macrovesicular steatosis with ballooning degeneration of hepatocytes, diffused lobular inflammation, and fibrosis. PPAR ligands are promising therapeutic agents in NASH; accordingly, we evaluated the effects of the first clinically available s...

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Detalles Bibliográficos
Autores principales: Sasaki, Yusuke, Asahiyama, Masato, Tanaka, Toshiya, Yamamoto, Shogo, Murakami, Kentaro, Kamiya, Wakana, Matsumura, Yoshihiro, Osawa, Tsuyoshi, Anai, Motonobu, Fruchart, Jean-Charles, Aburatani, Hiroyuki, Sakai, Juro, Kodama, Tatsuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210999/
https://www.ncbi.nlm.nih.gov/pubmed/32385406
http://dx.doi.org/10.1038/s41598-020-64902-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210999/
https://www.ncbi.nlm.nih.gov/pubmed/32385406
http://dx.doi.org/10.1038/s41598-020-64902-8

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