The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation

During β-adrenergic stimulation of brown adipose tissue (BAT), p38 phosphorylates the activating transcription factor 2 (ATF2) which then translocates to the nucleus to activate the expression of Ucp1 and Pgc-1α. The mechanisms underlying ATF2 target activation are unknown. Here we demonstrate that...

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Detalles Bibliográficos
Autores principales: Fischer, Katrin, Fenzl, Anna, Liu, Dianxin, Dyar, Kenneth A., Kleinert, Maximilian, Brielmeier, Markus, Clemmensen, Christoffer, Fedl, Anna, Finan, Brian, Gessner, Andre, Jastroch, Martin, Huang, Jianfeng, Keipert, Susanne, Klingenspor, Martin, Brüning, Jens C., Kneilling, Manfred, Maier, Florian C., Othman, Ahmed E., Pichler, Bernd J., Pramme-Steinwachs, Ines, Sachs, Stephan, Scheideler, Angelika, Thaiss, Wolfgang M., Uhlenhaut, Henriette, Ussar, Siegfried, Woods, Stephen C., Zorn, Julia, Stemmer, Kerstin, Collins, Sheila, Diaz-Meco, Maria, Moscat, Jorge, Tschöp, Matthias H., Müller, Timo D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211001/
https://www.ncbi.nlm.nih.gov/pubmed/32385399
http://dx.doi.org/10.1038/s41467-020-16230-8

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