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The role of growth factor receptors in viral infections: An opportunity for drug repurposing against emerging viral diseases such as COVID‐19?
Growth factor receptors are known to be involved in the process of viral infection. Many viruses not only use growth factor receptors to physically attach to the cell surface and internalize, but also divert receptor tyrosine kinase signaling in order to replicate. Thus, repurposing drugs that have...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211041/ https://www.ncbi.nlm.nih.gov/pubmed/32395702 http://dx.doi.org/10.1096/fba.2020-00015 |
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author | Hondermarck, Hubert Bartlett, Nathan W. Nurcombe, Victor |
author_facet | Hondermarck, Hubert Bartlett, Nathan W. Nurcombe, Victor |
author_sort | Hondermarck, Hubert |
collection | PubMed |
description | Growth factor receptors are known to be involved in the process of viral infection. Many viruses not only use growth factor receptors to physically attach to the cell surface and internalize, but also divert receptor tyrosine kinase signaling in order to replicate. Thus, repurposing drugs that have initially been developed to target growth factor receptors and their signaling in cancer may prove to be a fast track to effective therapies against emerging new viral infections, including the coronavirus disease 19 (COVID‐19). |
format | Online Article Text |
id | pubmed-7211041 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-72110412020-05-11 The role of growth factor receptors in viral infections: An opportunity for drug repurposing against emerging viral diseases such as COVID‐19? Hondermarck, Hubert Bartlett, Nathan W. Nurcombe, Victor FASEB Bioadv Hypothesis Growth factor receptors are known to be involved in the process of viral infection. Many viruses not only use growth factor receptors to physically attach to the cell surface and internalize, but also divert receptor tyrosine kinase signaling in order to replicate. Thus, repurposing drugs that have initially been developed to target growth factor receptors and their signaling in cancer may prove to be a fast track to effective therapies against emerging new viral infections, including the coronavirus disease 19 (COVID‐19). John Wiley and Sons Inc. 2020-04-11 /pmc/articles/PMC7211041/ /pubmed/32395702 http://dx.doi.org/10.1096/fba.2020-00015 Text en © 2020 The Authors. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Hypothesis Hondermarck, Hubert Bartlett, Nathan W. Nurcombe, Victor The role of growth factor receptors in viral infections: An opportunity for drug repurposing against emerging viral diseases such as COVID‐19? |
title | The role of growth factor receptors in viral infections: An opportunity for drug repurposing against emerging viral diseases such as COVID‐19? |
title_full | The role of growth factor receptors in viral infections: An opportunity for drug repurposing against emerging viral diseases such as COVID‐19? |
title_fullStr | The role of growth factor receptors in viral infections: An opportunity for drug repurposing against emerging viral diseases such as COVID‐19? |
title_full_unstemmed | The role of growth factor receptors in viral infections: An opportunity for drug repurposing against emerging viral diseases such as COVID‐19? |
title_short | The role of growth factor receptors in viral infections: An opportunity for drug repurposing against emerging viral diseases such as COVID‐19? |
title_sort | role of growth factor receptors in viral infections: an opportunity for drug repurposing against emerging viral diseases such as covid‐19? |
topic | Hypothesis |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211041/ https://www.ncbi.nlm.nih.gov/pubmed/32395702 http://dx.doi.org/10.1096/fba.2020-00015 |
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