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The role of growth factor receptors in viral infections: An opportunity for drug repurposing against emerging viral diseases such as COVID‐19?

Growth factor receptors are known to be involved in the process of viral infection. Many viruses not only use growth factor receptors to physically attach to the cell surface and internalize, but also divert receptor tyrosine kinase signaling in order to replicate. Thus, repurposing drugs that have...

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Detalles Bibliográficos
Autores principales: Hondermarck, Hubert, Bartlett, Nathan W., Nurcombe, Victor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211041/
https://www.ncbi.nlm.nih.gov/pubmed/32395702
http://dx.doi.org/10.1096/fba.2020-00015
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author Hondermarck, Hubert
Bartlett, Nathan W.
Nurcombe, Victor
author_facet Hondermarck, Hubert
Bartlett, Nathan W.
Nurcombe, Victor
author_sort Hondermarck, Hubert
collection PubMed
description Growth factor receptors are known to be involved in the process of viral infection. Many viruses not only use growth factor receptors to physically attach to the cell surface and internalize, but also divert receptor tyrosine kinase signaling in order to replicate. Thus, repurposing drugs that have initially been developed to target growth factor receptors and their signaling in cancer may prove to be a fast track to effective therapies against emerging new viral infections, including the coronavirus disease 19 (COVID‐19).
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spelling pubmed-72110412020-05-11 The role of growth factor receptors in viral infections: An opportunity for drug repurposing against emerging viral diseases such as COVID‐19? Hondermarck, Hubert Bartlett, Nathan W. Nurcombe, Victor FASEB Bioadv Hypothesis Growth factor receptors are known to be involved in the process of viral infection. Many viruses not only use growth factor receptors to physically attach to the cell surface and internalize, but also divert receptor tyrosine kinase signaling in order to replicate. Thus, repurposing drugs that have initially been developed to target growth factor receptors and their signaling in cancer may prove to be a fast track to effective therapies against emerging new viral infections, including the coronavirus disease 19 (COVID‐19). John Wiley and Sons Inc. 2020-04-11 /pmc/articles/PMC7211041/ /pubmed/32395702 http://dx.doi.org/10.1096/fba.2020-00015 Text en © 2020 The Authors. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Hypothesis
Hondermarck, Hubert
Bartlett, Nathan W.
Nurcombe, Victor
The role of growth factor receptors in viral infections: An opportunity for drug repurposing against emerging viral diseases such as COVID‐19?
title The role of growth factor receptors in viral infections: An opportunity for drug repurposing against emerging viral diseases such as COVID‐19?
title_full The role of growth factor receptors in viral infections: An opportunity for drug repurposing against emerging viral diseases such as COVID‐19?
title_fullStr The role of growth factor receptors in viral infections: An opportunity for drug repurposing against emerging viral diseases such as COVID‐19?
title_full_unstemmed The role of growth factor receptors in viral infections: An opportunity for drug repurposing against emerging viral diseases such as COVID‐19?
title_short The role of growth factor receptors in viral infections: An opportunity for drug repurposing against emerging viral diseases such as COVID‐19?
title_sort role of growth factor receptors in viral infections: an opportunity for drug repurposing against emerging viral diseases such as covid‐19?
topic Hypothesis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211041/
https://www.ncbi.nlm.nih.gov/pubmed/32395702
http://dx.doi.org/10.1096/fba.2020-00015
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