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The Effect of Intracoronary Infusion of Autologous Bone Marrow-Derived Lineage-Negative Stem/Progenitor Cells on Remodeling of Post-Infarcted Heart in Patient with Acute Myocardial Infarction

Introduction: Regenerative capacity of the heart is limited, and the post-infarct left ventricle (LV) dysfunction is associated with poor prognosis. Administration of stem/progenitor cells (SPCs) is a promising approach for cardiac regeneration. Objectives: In the study, we assessed LV function and...

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Autores principales: Peregud-Pogorzelska, Małgorzata, Przybycień, Krzysztof, Baumert, Bartłomiej, Kotowski, Maciej, Pius-Sadowska, Ewa, Safranow, Krzysztof, Peregud-Pogorzelski, Jarosław, Kornacewicz-Jach, Zdzisława, Paczkowska, Edyta, Machaliński, Bogusław
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211150/
https://www.ncbi.nlm.nih.gov/pubmed/32410827
http://dx.doi.org/10.7150/ijms.42561
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author Peregud-Pogorzelska, Małgorzata
Przybycień, Krzysztof
Baumert, Bartłomiej
Kotowski, Maciej
Pius-Sadowska, Ewa
Safranow, Krzysztof
Peregud-Pogorzelski, Jarosław
Kornacewicz-Jach, Zdzisława
Paczkowska, Edyta
Machaliński, Bogusław
author_facet Peregud-Pogorzelska, Małgorzata
Przybycień, Krzysztof
Baumert, Bartłomiej
Kotowski, Maciej
Pius-Sadowska, Ewa
Safranow, Krzysztof
Peregud-Pogorzelski, Jarosław
Kornacewicz-Jach, Zdzisława
Paczkowska, Edyta
Machaliński, Bogusław
author_sort Peregud-Pogorzelska, Małgorzata
collection PubMed
description Introduction: Regenerative capacity of the heart is limited, and the post-infarct left ventricle (LV) dysfunction is associated with poor prognosis. Administration of stem/progenitor cells (SPCs) is a promising approach for cardiac regeneration. Objectives: In the study, we assessed LV function and post-infarcted remodeling in patients with ST-elevated myocardial infarct (STEMI) who received autologous lineage-negative (LIN(-)) SPCs. Patients and methods: Patients with STEMI and one-vessel coronary artery disease treated with percutaneous revascularisation were divided into study group (LIN(-) group, 15 patients) that received standard therapy and autologous BM-derived LIN(-) SPCs and control group (standard therapy group, 19 patients). The cells were administered intracoronary 24 hours after STEMI. The follow-up was 12 months with subsequent non-invasive tests and laboratory parameter evaluation on days 1(st), 3(rd), and 7(th) as well as at 1(st), 3(rd), 6(th) and 12(th) month after STEMI. Results: All procedures related to SPCs administration were well tolerated by the patients. In 12-month follow-up, there were no major adverse cardiac events connected with LIN(-) SPCs administration. During 12-month follow-up, 9 patients from LIN(-) group (Responders) achieved an improvement in LV ejection fraction (>10% after 12 months) with no signs of unfavorable LV remodeling. Laboratory parameters analysis showed that Troponin T levels were significantly lower until day 7(th) in the Responders group, while brain natriuretic peptide (BNP) level remained significantly lower from day 3(rd) to 12(th) month respectively. Conclusions: Intracoronary infusion of autologous BM-derived LIN(-) stem/progenitor cells is feasible and safe for patient. Improvement in LV function and prevention of unfavorable remodeling in the 60% of study group seems relatively promising. Stem cell-based therapy for cardiac regeneration still needs more accurate and extensive investigations to estimate and improve their efficacy.
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spelling pubmed-72111502020-05-14 The Effect of Intracoronary Infusion of Autologous Bone Marrow-Derived Lineage-Negative Stem/Progenitor Cells on Remodeling of Post-Infarcted Heart in Patient with Acute Myocardial Infarction Peregud-Pogorzelska, Małgorzata Przybycień, Krzysztof Baumert, Bartłomiej Kotowski, Maciej Pius-Sadowska, Ewa Safranow, Krzysztof Peregud-Pogorzelski, Jarosław Kornacewicz-Jach, Zdzisława Paczkowska, Edyta Machaliński, Bogusław Int J Med Sci Research Paper Introduction: Regenerative capacity of the heart is limited, and the post-infarct left ventricle (LV) dysfunction is associated with poor prognosis. Administration of stem/progenitor cells (SPCs) is a promising approach for cardiac regeneration. Objectives: In the study, we assessed LV function and post-infarcted remodeling in patients with ST-elevated myocardial infarct (STEMI) who received autologous lineage-negative (LIN(-)) SPCs. Patients and methods: Patients with STEMI and one-vessel coronary artery disease treated with percutaneous revascularisation were divided into study group (LIN(-) group, 15 patients) that received standard therapy and autologous BM-derived LIN(-) SPCs and control group (standard therapy group, 19 patients). The cells were administered intracoronary 24 hours after STEMI. The follow-up was 12 months with subsequent non-invasive tests and laboratory parameter evaluation on days 1(st), 3(rd), and 7(th) as well as at 1(st), 3(rd), 6(th) and 12(th) month after STEMI. Results: All procedures related to SPCs administration were well tolerated by the patients. In 12-month follow-up, there were no major adverse cardiac events connected with LIN(-) SPCs administration. During 12-month follow-up, 9 patients from LIN(-) group (Responders) achieved an improvement in LV ejection fraction (>10% after 12 months) with no signs of unfavorable LV remodeling. Laboratory parameters analysis showed that Troponin T levels were significantly lower until day 7(th) in the Responders group, while brain natriuretic peptide (BNP) level remained significantly lower from day 3(rd) to 12(th) month respectively. Conclusions: Intracoronary infusion of autologous BM-derived LIN(-) stem/progenitor cells is feasible and safe for patient. Improvement in LV function and prevention of unfavorable remodeling in the 60% of study group seems relatively promising. Stem cell-based therapy for cardiac regeneration still needs more accurate and extensive investigations to estimate and improve their efficacy. Ivyspring International Publisher 2020-04-06 /pmc/articles/PMC7211150/ /pubmed/32410827 http://dx.doi.org/10.7150/ijms.42561 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Peregud-Pogorzelska, Małgorzata
Przybycień, Krzysztof
Baumert, Bartłomiej
Kotowski, Maciej
Pius-Sadowska, Ewa
Safranow, Krzysztof
Peregud-Pogorzelski, Jarosław
Kornacewicz-Jach, Zdzisława
Paczkowska, Edyta
Machaliński, Bogusław
The Effect of Intracoronary Infusion of Autologous Bone Marrow-Derived Lineage-Negative Stem/Progenitor Cells on Remodeling of Post-Infarcted Heart in Patient with Acute Myocardial Infarction
title The Effect of Intracoronary Infusion of Autologous Bone Marrow-Derived Lineage-Negative Stem/Progenitor Cells on Remodeling of Post-Infarcted Heart in Patient with Acute Myocardial Infarction
title_full The Effect of Intracoronary Infusion of Autologous Bone Marrow-Derived Lineage-Negative Stem/Progenitor Cells on Remodeling of Post-Infarcted Heart in Patient with Acute Myocardial Infarction
title_fullStr The Effect of Intracoronary Infusion of Autologous Bone Marrow-Derived Lineage-Negative Stem/Progenitor Cells on Remodeling of Post-Infarcted Heart in Patient with Acute Myocardial Infarction
title_full_unstemmed The Effect of Intracoronary Infusion of Autologous Bone Marrow-Derived Lineage-Negative Stem/Progenitor Cells on Remodeling of Post-Infarcted Heart in Patient with Acute Myocardial Infarction
title_short The Effect of Intracoronary Infusion of Autologous Bone Marrow-Derived Lineage-Negative Stem/Progenitor Cells on Remodeling of Post-Infarcted Heart in Patient with Acute Myocardial Infarction
title_sort effect of intracoronary infusion of autologous bone marrow-derived lineage-negative stem/progenitor cells on remodeling of post-infarcted heart in patient with acute myocardial infarction
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211150/
https://www.ncbi.nlm.nih.gov/pubmed/32410827
http://dx.doi.org/10.7150/ijms.42561
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