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Exosomes in osteoarthritis and cartilage injury: advanced development and potential therapeutic strategies
Articular cartilage injury is a common clinical problem, which can lead to joint dysfunction, significant pain, and secondary osteoarthritis (OA) in which major surgical procedures are mandatory for treatment. Exosomes, as endosome-derived membrane-bound vesicles, participating in intercellular comm...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211167/ https://www.ncbi.nlm.nih.gov/pubmed/32398951 http://dx.doi.org/10.7150/ijbs.41637 |
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author | Zhou, Quanfa Cai, Youzhi Jiang, Yangzi Lin, Xiangjin |
author_facet | Zhou, Quanfa Cai, Youzhi Jiang, Yangzi Lin, Xiangjin |
author_sort | Zhou, Quanfa |
collection | PubMed |
description | Articular cartilage injury is a common clinical problem, which can lead to joint dysfunction, significant pain, and secondary osteoarthritis (OA) in which major surgical procedures are mandatory for treatment. Exosomes, as endosome-derived membrane-bound vesicles, participating in intercellular communications in both physiological and pathophysiological conditions, have been attached great importance in many fields. Recently, the significance of exosomes in the development of OA has been gradually concerned, while the therapeutic value of exosomes in cartilage repair and OA treatment has also been gradually revealed. The functional difference of different types and derivations of exosomes are determined by their specific contents. Herein, we provide comprehensive understanding on exosome and OA, including how exosomes participating in OA, the therapeutic value of exosomes for cartilage injury/OA, and related bioengineering strategies for future therapeutic design. |
format | Online Article Text |
id | pubmed-7211167 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-72111672020-05-12 Exosomes in osteoarthritis and cartilage injury: advanced development and potential therapeutic strategies Zhou, Quanfa Cai, Youzhi Jiang, Yangzi Lin, Xiangjin Int J Biol Sci Review Articular cartilage injury is a common clinical problem, which can lead to joint dysfunction, significant pain, and secondary osteoarthritis (OA) in which major surgical procedures are mandatory for treatment. Exosomes, as endosome-derived membrane-bound vesicles, participating in intercellular communications in both physiological and pathophysiological conditions, have been attached great importance in many fields. Recently, the significance of exosomes in the development of OA has been gradually concerned, while the therapeutic value of exosomes in cartilage repair and OA treatment has also been gradually revealed. The functional difference of different types and derivations of exosomes are determined by their specific contents. Herein, we provide comprehensive understanding on exosome and OA, including how exosomes participating in OA, the therapeutic value of exosomes for cartilage injury/OA, and related bioengineering strategies for future therapeutic design. Ivyspring International Publisher 2020-03-31 /pmc/articles/PMC7211167/ /pubmed/32398951 http://dx.doi.org/10.7150/ijbs.41637 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Review Zhou, Quanfa Cai, Youzhi Jiang, Yangzi Lin, Xiangjin Exosomes in osteoarthritis and cartilage injury: advanced development and potential therapeutic strategies |
title | Exosomes in osteoarthritis and cartilage injury: advanced development and potential therapeutic strategies |
title_full | Exosomes in osteoarthritis and cartilage injury: advanced development and potential therapeutic strategies |
title_fullStr | Exosomes in osteoarthritis and cartilage injury: advanced development and potential therapeutic strategies |
title_full_unstemmed | Exosomes in osteoarthritis and cartilage injury: advanced development and potential therapeutic strategies |
title_short | Exosomes in osteoarthritis and cartilage injury: advanced development and potential therapeutic strategies |
title_sort | exosomes in osteoarthritis and cartilage injury: advanced development and potential therapeutic strategies |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211167/ https://www.ncbi.nlm.nih.gov/pubmed/32398951 http://dx.doi.org/10.7150/ijbs.41637 |
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