Cargando…
Clinical-pathological and sociodemographic factors associated with the distant metastasis and overall survival of oral cavity and oropharynx squamous cell carcinoma
BACKGROUND: The objective of this study was to evaluate the influence of clinical-pathological and sociodemographic factors on the prevalence of distant metastasis (DM) and overall survival in patients with oral cavity and oropharynx squamous cell carcinoma (OOSCC). MATERIAL AND METHODS: Cross-secti...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medicina Oral S.L.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211363/ https://www.ncbi.nlm.nih.gov/pubmed/32271320 http://dx.doi.org/10.4317/medoral.23410 |
_version_ | 1783531442067734528 |
---|---|
author | de Barros-Silva, Paulo Goberlânio Fontes-Borges, Marcela Maria Costa-Dias, Camila Mota-Lemos, José Vitor Socorro-Saldanha-Cunha, Maria do Perpétuo Fernandes-Souza, Eric Sousa-Dantas, Thinali Bitu-Sousa, Fabrício |
author_facet | de Barros-Silva, Paulo Goberlânio Fontes-Borges, Marcela Maria Costa-Dias, Camila Mota-Lemos, José Vitor Socorro-Saldanha-Cunha, Maria do Perpétuo Fernandes-Souza, Eric Sousa-Dantas, Thinali Bitu-Sousa, Fabrício |
author_sort | de Barros-Silva, Paulo Goberlânio |
collection | PubMed |
description | BACKGROUND: The objective of this study was to evaluate the influence of clinical-pathological and sociodemographic factors on the prevalence of distant metastasis (DM) and overall survival in patients with oral cavity and oropharynx squamous cell carcinoma (OOSCC). MATERIAL AND METHODS: Cross-sectional study based on the records of 404 OOSCC patients evaluated for DM, covering the period 2000-2014. We analysed the influence of age, sex, level of schooling, primary tumor subsite, treatment, marital status, family history of cancer, history of smoking and alcohol consumption, type of health care coverage (private vs. public) and overall survival. Findings were submitted to Fisher’s exact test, Pearson’s chi-squared test, Mantel-Cox log-rank testing and multinomial and Cox regression analysis (SPSS v. 20.0; p<0.05). RESULTS: The prevalence of DM was 5.4% (22/404). The respiratory tract was the most affected DM site (n=9; 40.9%). Male sex (p=0.049), oropharyngeal primary tumor (p=0.008), stage T3-4 (p=0.022), lymph node metastasis (N+) (p<0.001) and palliative treatment (p=0.005) were directly associated with DM. Patients with oral primary tumours (p=0.343) and primary oropharyngeal tumours (p=0.242) did not differ significantly with regard to the prevalence of DM. N+ was an independent risk factor for DM (p=0.017). Five variables independently reduced overall survival: male sex (p=0.035), age >65 years (p=0.046), indigenous/brown racial type (p=0.045), palliative treatment (p=0.035) and DM (p=0.048). CONCLUSIONS: Lymph node metastasis independently increased the prevalence of DM and, along with male sex, older age, brown racial type and palliative treatment, was independently associated with poor prognosis in patients with OOSCC. Key words:Neoplasm metastasis, mouth neoplasms, prognosis, carcinoma, squamous cell. |
format | Online Article Text |
id | pubmed-7211363 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Medicina Oral S.L. |
record_format | MEDLINE/PubMed |
spelling | pubmed-72113632020-05-14 Clinical-pathological and sociodemographic factors associated with the distant metastasis and overall survival of oral cavity and oropharynx squamous cell carcinoma de Barros-Silva, Paulo Goberlânio Fontes-Borges, Marcela Maria Costa-Dias, Camila Mota-Lemos, José Vitor Socorro-Saldanha-Cunha, Maria do Perpétuo Fernandes-Souza, Eric Sousa-Dantas, Thinali Bitu-Sousa, Fabrício Med Oral Patol Oral Cir Bucal Research BACKGROUND: The objective of this study was to evaluate the influence of clinical-pathological and sociodemographic factors on the prevalence of distant metastasis (DM) and overall survival in patients with oral cavity and oropharynx squamous cell carcinoma (OOSCC). MATERIAL AND METHODS: Cross-sectional study based on the records of 404 OOSCC patients evaluated for DM, covering the period 2000-2014. We analysed the influence of age, sex, level of schooling, primary tumor subsite, treatment, marital status, family history of cancer, history of smoking and alcohol consumption, type of health care coverage (private vs. public) and overall survival. Findings were submitted to Fisher’s exact test, Pearson’s chi-squared test, Mantel-Cox log-rank testing and multinomial and Cox regression analysis (SPSS v. 20.0; p<0.05). RESULTS: The prevalence of DM was 5.4% (22/404). The respiratory tract was the most affected DM site (n=9; 40.9%). Male sex (p=0.049), oropharyngeal primary tumor (p=0.008), stage T3-4 (p=0.022), lymph node metastasis (N+) (p<0.001) and palliative treatment (p=0.005) were directly associated with DM. Patients with oral primary tumours (p=0.343) and primary oropharyngeal tumours (p=0.242) did not differ significantly with regard to the prevalence of DM. N+ was an independent risk factor for DM (p=0.017). Five variables independently reduced overall survival: male sex (p=0.035), age >65 years (p=0.046), indigenous/brown racial type (p=0.045), palliative treatment (p=0.035) and DM (p=0.048). CONCLUSIONS: Lymph node metastasis independently increased the prevalence of DM and, along with male sex, older age, brown racial type and palliative treatment, was independently associated with poor prognosis in patients with OOSCC. Key words:Neoplasm metastasis, mouth neoplasms, prognosis, carcinoma, squamous cell. Medicina Oral S.L. 2020-05 2020-04-09 /pmc/articles/PMC7211363/ /pubmed/32271320 http://dx.doi.org/10.4317/medoral.23410 Text en Copyright: © 2020 Medicina Oral S.L. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research de Barros-Silva, Paulo Goberlânio Fontes-Borges, Marcela Maria Costa-Dias, Camila Mota-Lemos, José Vitor Socorro-Saldanha-Cunha, Maria do Perpétuo Fernandes-Souza, Eric Sousa-Dantas, Thinali Bitu-Sousa, Fabrício Clinical-pathological and sociodemographic factors associated with the distant metastasis and overall survival of oral cavity and oropharynx squamous cell carcinoma |
title | Clinical-pathological and sociodemographic factors associated with the distant metastasis and overall survival of oral cavity and oropharynx squamous cell carcinoma |
title_full | Clinical-pathological and sociodemographic factors associated with the distant metastasis and overall survival of oral cavity and oropharynx squamous cell carcinoma |
title_fullStr | Clinical-pathological and sociodemographic factors associated with the distant metastasis and overall survival of oral cavity and oropharynx squamous cell carcinoma |
title_full_unstemmed | Clinical-pathological and sociodemographic factors associated with the distant metastasis and overall survival of oral cavity and oropharynx squamous cell carcinoma |
title_short | Clinical-pathological and sociodemographic factors associated with the distant metastasis and overall survival of oral cavity and oropharynx squamous cell carcinoma |
title_sort | clinical-pathological and sociodemographic factors associated with the distant metastasis and overall survival of oral cavity and oropharynx squamous cell carcinoma |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211363/ https://www.ncbi.nlm.nih.gov/pubmed/32271320 http://dx.doi.org/10.4317/medoral.23410 |
work_keys_str_mv | AT debarrossilvapaulogoberlanio clinicalpathologicalandsociodemographicfactorsassociatedwiththedistantmetastasisandoverallsurvivaloforalcavityandoropharynxsquamouscellcarcinoma AT fontesborgesmarcelamaria clinicalpathologicalandsociodemographicfactorsassociatedwiththedistantmetastasisandoverallsurvivaloforalcavityandoropharynxsquamouscellcarcinoma AT costadiascamila clinicalpathologicalandsociodemographicfactorsassociatedwiththedistantmetastasisandoverallsurvivaloforalcavityandoropharynxsquamouscellcarcinoma AT motalemosjosevitor clinicalpathologicalandsociodemographicfactorsassociatedwiththedistantmetastasisandoverallsurvivaloforalcavityandoropharynxsquamouscellcarcinoma AT socorrosaldanhacunhamariadoperpetuo clinicalpathologicalandsociodemographicfactorsassociatedwiththedistantmetastasisandoverallsurvivaloforalcavityandoropharynxsquamouscellcarcinoma AT fernandessouzaeric clinicalpathologicalandsociodemographicfactorsassociatedwiththedistantmetastasisandoverallsurvivaloforalcavityandoropharynxsquamouscellcarcinoma AT sousadantasthinali clinicalpathologicalandsociodemographicfactorsassociatedwiththedistantmetastasisandoverallsurvivaloforalcavityandoropharynxsquamouscellcarcinoma AT bitusousafabricio clinicalpathologicalandsociodemographicfactorsassociatedwiththedistantmetastasisandoverallsurvivaloforalcavityandoropharynxsquamouscellcarcinoma |