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Autopsy findings from the first known death from Severe Acute Respiratory Syndrome SARS-CoV-2 in Spain
The new coronavirus SARS-CoV-2, first identified in Wuhan, China in December, 2019, can cause Severe Acute Respiratory Syndrome (SARS) with massive alveolar damage and progressive respiratory failure. We present the relevant autopsy findings of the first patient known to have died from COVID19 pneum...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedad Española de Anatomía Patológica. Published by Elsevier España, S.L.U.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211676/ https://www.ncbi.nlm.nih.gov/pubmed/32650970 http://dx.doi.org/10.1016/j.patol.2020.04.002 |
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author | Navarro Conde, Pedro Alemany Monraval, Pilar Medina Medina, Carmen Jiménez Sánchez, Ana Andrés Teruel, Juan Carlos Ferrando Marco, José Puglia Santos, Víctor Mayordomo Aranda, Empar |
author_facet | Navarro Conde, Pedro Alemany Monraval, Pilar Medina Medina, Carmen Jiménez Sánchez, Ana Andrés Teruel, Juan Carlos Ferrando Marco, José Puglia Santos, Víctor Mayordomo Aranda, Empar |
author_sort | Navarro Conde, Pedro |
collection | PubMed |
description | The new coronavirus SARS-CoV-2, first identified in Wuhan, China in December, 2019, can cause Severe Acute Respiratory Syndrome (SARS) with massive alveolar damage and progressive respiratory failure. We present the relevant autopsy findings of the first patient known to have died from COVID19 pneumonia in Spain, carried out on the 14(th) of February, 2020, in our hospital (Hospital Arnau de Vilanova-Lliria, Valencia). Histological examination revealed typical changes of diffuse alveolar damage (DAD) in both the exudative and proliferative phase of acute lung injury. Intra-alveolar multinucleated giant cells, smudge cells and vascular thrombosis were present. The diagnosis was confirmed by reverse real-time PCR assay on a throat swab sample taken during the patient's admission. The positive result was reported fifteen days subsequent to autopsy. |
format | Online Article Text |
id | pubmed-7211676 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Sociedad Española de Anatomía Patológica. Published by Elsevier España, S.L.U. |
record_format | MEDLINE/PubMed |
spelling | pubmed-72116762020-05-11 Autopsy findings from the first known death from Severe Acute Respiratory Syndrome SARS-CoV-2 in Spain Navarro Conde, Pedro Alemany Monraval, Pilar Medina Medina, Carmen Jiménez Sánchez, Ana Andrés Teruel, Juan Carlos Ferrando Marco, José Puglia Santos, Víctor Mayordomo Aranda, Empar Rev Esp Patol Article The new coronavirus SARS-CoV-2, first identified in Wuhan, China in December, 2019, can cause Severe Acute Respiratory Syndrome (SARS) with massive alveolar damage and progressive respiratory failure. We present the relevant autopsy findings of the first patient known to have died from COVID19 pneumonia in Spain, carried out on the 14(th) of February, 2020, in our hospital (Hospital Arnau de Vilanova-Lliria, Valencia). Histological examination revealed typical changes of diffuse alveolar damage (DAD) in both the exudative and proliferative phase of acute lung injury. Intra-alveolar multinucleated giant cells, smudge cells and vascular thrombosis were present. The diagnosis was confirmed by reverse real-time PCR assay on a throat swab sample taken during the patient's admission. The positive result was reported fifteen days subsequent to autopsy. Sociedad Española de Anatomía Patológica. Published by Elsevier España, S.L.U. 2020 2020-05-11 /pmc/articles/PMC7211676/ /pubmed/32650970 http://dx.doi.org/10.1016/j.patol.2020.04.002 Text en © 2020 Sociedad Española de Anatomía Patológica. Published by Elsevier España, S.L.U. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Navarro Conde, Pedro Alemany Monraval, Pilar Medina Medina, Carmen Jiménez Sánchez, Ana Andrés Teruel, Juan Carlos Ferrando Marco, José Puglia Santos, Víctor Mayordomo Aranda, Empar Autopsy findings from the first known death from Severe Acute Respiratory Syndrome SARS-CoV-2 in Spain |
title | Autopsy findings from the first known death from Severe Acute Respiratory Syndrome SARS-CoV-2 in Spain |
title_full | Autopsy findings from the first known death from Severe Acute Respiratory Syndrome SARS-CoV-2 in Spain |
title_fullStr | Autopsy findings from the first known death from Severe Acute Respiratory Syndrome SARS-CoV-2 in Spain |
title_full_unstemmed | Autopsy findings from the first known death from Severe Acute Respiratory Syndrome SARS-CoV-2 in Spain |
title_short | Autopsy findings from the first known death from Severe Acute Respiratory Syndrome SARS-CoV-2 in Spain |
title_sort | autopsy findings from the first known death from severe acute respiratory syndrome sars-cov-2 in spain |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211676/ https://www.ncbi.nlm.nih.gov/pubmed/32650970 http://dx.doi.org/10.1016/j.patol.2020.04.002 |
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