Cargando…
A systematic review on use of aminoquinolines for the therapeutic management of COVID-19: Efficacy, safety and clinical trials
Recent global outbreak of the pandemic caused by coronavirus (COVID-19) emphasizes the urgent need for novel antiviral therapeutics. It can be supplemented by utilization of efficient and validated drug discovery approaches such as drug repurposing/repositioning. The well reported and clinically use...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Inc.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211740/ https://www.ncbi.nlm.nih.gov/pubmed/32418894 http://dx.doi.org/10.1016/j.lfs.2020.117775 |
_version_ | 1783531506885459968 |
---|---|
author | Patil, Vaishali M. Singhal, Shipra Masand, Neeraj |
author_facet | Patil, Vaishali M. Singhal, Shipra Masand, Neeraj |
author_sort | Patil, Vaishali M. |
collection | PubMed |
description | Recent global outbreak of the pandemic caused by coronavirus (COVID-19) emphasizes the urgent need for novel antiviral therapeutics. It can be supplemented by utilization of efficient and validated drug discovery approaches such as drug repurposing/repositioning. The well reported and clinically used anti-malarial aminoquinoline drugs (chloroquine and hydroxychloroquine) have shown potential to be repurposed to control the present pandemic by inhibition of COVID-19. The review elaborates the mechanism of action, safety (side effects, adverse effects, toxicity) and details of clinical trials for chloroquine and hydroxychloroquine to benefit the clinicians, medicinal chemist, pharmacologist actively involved in controlling the pandemic and to provide therapeutics for the treatment of COVID-19 infection. |
format | Online Article Text |
id | pubmed-7211740 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-72117402020-05-11 A systematic review on use of aminoquinolines for the therapeutic management of COVID-19: Efficacy, safety and clinical trials Patil, Vaishali M. Singhal, Shipra Masand, Neeraj Life Sci Article Recent global outbreak of the pandemic caused by coronavirus (COVID-19) emphasizes the urgent need for novel antiviral therapeutics. It can be supplemented by utilization of efficient and validated drug discovery approaches such as drug repurposing/repositioning. The well reported and clinically used anti-malarial aminoquinoline drugs (chloroquine and hydroxychloroquine) have shown potential to be repurposed to control the present pandemic by inhibition of COVID-19. The review elaborates the mechanism of action, safety (side effects, adverse effects, toxicity) and details of clinical trials for chloroquine and hydroxychloroquine to benefit the clinicians, medicinal chemist, pharmacologist actively involved in controlling the pandemic and to provide therapeutics for the treatment of COVID-19 infection. Elsevier Inc. 2020-08-01 2020-05-11 /pmc/articles/PMC7211740/ /pubmed/32418894 http://dx.doi.org/10.1016/j.lfs.2020.117775 Text en © 2020 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Patil, Vaishali M. Singhal, Shipra Masand, Neeraj A systematic review on use of aminoquinolines for the therapeutic management of COVID-19: Efficacy, safety and clinical trials |
title | A systematic review on use of aminoquinolines for the therapeutic management of COVID-19: Efficacy, safety and clinical trials |
title_full | A systematic review on use of aminoquinolines for the therapeutic management of COVID-19: Efficacy, safety and clinical trials |
title_fullStr | A systematic review on use of aminoquinolines for the therapeutic management of COVID-19: Efficacy, safety and clinical trials |
title_full_unstemmed | A systematic review on use of aminoquinolines for the therapeutic management of COVID-19: Efficacy, safety and clinical trials |
title_short | A systematic review on use of aminoquinolines for the therapeutic management of COVID-19: Efficacy, safety and clinical trials |
title_sort | systematic review on use of aminoquinolines for the therapeutic management of covid-19: efficacy, safety and clinical trials |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211740/ https://www.ncbi.nlm.nih.gov/pubmed/32418894 http://dx.doi.org/10.1016/j.lfs.2020.117775 |
work_keys_str_mv | AT patilvaishalim asystematicreviewonuseofaminoquinolinesforthetherapeuticmanagementofcovid19efficacysafetyandclinicaltrials AT singhalshipra asystematicreviewonuseofaminoquinolinesforthetherapeuticmanagementofcovid19efficacysafetyandclinicaltrials AT masandneeraj asystematicreviewonuseofaminoquinolinesforthetherapeuticmanagementofcovid19efficacysafetyandclinicaltrials AT patilvaishalim systematicreviewonuseofaminoquinolinesforthetherapeuticmanagementofcovid19efficacysafetyandclinicaltrials AT singhalshipra systematicreviewonuseofaminoquinolinesforthetherapeuticmanagementofcovid19efficacysafetyandclinicaltrials AT masandneeraj systematicreviewonuseofaminoquinolinesforthetherapeuticmanagementofcovid19efficacysafetyandclinicaltrials |