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A systematic review on use of aminoquinolines for the therapeutic management of COVID-19: Efficacy, safety and clinical trials

Recent global outbreak of the pandemic caused by coronavirus (COVID-19) emphasizes the urgent need for novel antiviral therapeutics. It can be supplemented by utilization of efficient and validated drug discovery approaches such as drug repurposing/repositioning. The well reported and clinically use...

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Detalles Bibliográficos
Autores principales: Patil, Vaishali M., Singhal, Shipra, Masand, Neeraj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211740/
https://www.ncbi.nlm.nih.gov/pubmed/32418894
http://dx.doi.org/10.1016/j.lfs.2020.117775
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author Patil, Vaishali M.
Singhal, Shipra
Masand, Neeraj
author_facet Patil, Vaishali M.
Singhal, Shipra
Masand, Neeraj
author_sort Patil, Vaishali M.
collection PubMed
description Recent global outbreak of the pandemic caused by coronavirus (COVID-19) emphasizes the urgent need for novel antiviral therapeutics. It can be supplemented by utilization of efficient and validated drug discovery approaches such as drug repurposing/repositioning. The well reported and clinically used anti-malarial aminoquinoline drugs (chloroquine and hydroxychloroquine) have shown potential to be repurposed to control the present pandemic by inhibition of COVID-19. The review elaborates the mechanism of action, safety (side effects, adverse effects, toxicity) and details of clinical trials for chloroquine and hydroxychloroquine to benefit the clinicians, medicinal chemist, pharmacologist actively involved in controlling the pandemic and to provide therapeutics for the treatment of COVID-19 infection.
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spelling pubmed-72117402020-05-11 A systematic review on use of aminoquinolines for the therapeutic management of COVID-19: Efficacy, safety and clinical trials Patil, Vaishali M. Singhal, Shipra Masand, Neeraj Life Sci Article Recent global outbreak of the pandemic caused by coronavirus (COVID-19) emphasizes the urgent need for novel antiviral therapeutics. It can be supplemented by utilization of efficient and validated drug discovery approaches such as drug repurposing/repositioning. The well reported and clinically used anti-malarial aminoquinoline drugs (chloroquine and hydroxychloroquine) have shown potential to be repurposed to control the present pandemic by inhibition of COVID-19. The review elaborates the mechanism of action, safety (side effects, adverse effects, toxicity) and details of clinical trials for chloroquine and hydroxychloroquine to benefit the clinicians, medicinal chemist, pharmacologist actively involved in controlling the pandemic and to provide therapeutics for the treatment of COVID-19 infection. Elsevier Inc. 2020-08-01 2020-05-11 /pmc/articles/PMC7211740/ /pubmed/32418894 http://dx.doi.org/10.1016/j.lfs.2020.117775 Text en © 2020 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Patil, Vaishali M.
Singhal, Shipra
Masand, Neeraj
A systematic review on use of aminoquinolines for the therapeutic management of COVID-19: Efficacy, safety and clinical trials
title A systematic review on use of aminoquinolines for the therapeutic management of COVID-19: Efficacy, safety and clinical trials
title_full A systematic review on use of aminoquinolines for the therapeutic management of COVID-19: Efficacy, safety and clinical trials
title_fullStr A systematic review on use of aminoquinolines for the therapeutic management of COVID-19: Efficacy, safety and clinical trials
title_full_unstemmed A systematic review on use of aminoquinolines for the therapeutic management of COVID-19: Efficacy, safety and clinical trials
title_short A systematic review on use of aminoquinolines for the therapeutic management of COVID-19: Efficacy, safety and clinical trials
title_sort systematic review on use of aminoquinolines for the therapeutic management of covid-19: efficacy, safety and clinical trials
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211740/
https://www.ncbi.nlm.nih.gov/pubmed/32418894
http://dx.doi.org/10.1016/j.lfs.2020.117775
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