High-throughput antibody screening from complex matrices using intact protein electrospray mass spectrometry

Toward the goal of increasing the throughput of high-resolution mass characterization of intact antibodies, we developed a RapidFire–mass spectrometry (MS) assay using electrospray ionization. We achieved unprecedented screening throughput as fast as 15 s/sample, which is an order of magnitude impro...

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Detalles Bibliográficos
Autores principales: Sawyer, William S., Srikumar, Neha, Carver, Joseph, Chu, Phillip Y., Shen, Amy, Xu, Ankai, Williams, Ambrose J., Spiess, Christoph, Wu, Cong, Liu, Yichin, Tran, John C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211930/
https://www.ncbi.nlm.nih.gov/pubmed/32327606
http://dx.doi.org/10.1073/pnas.1917383117

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