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COVID-19 in people living with human immunodeficiency virus: a case series of 33 patients

INTRODUCTION: Data on people living with human immunodeficiency virus (PLWH) in the current SARS-CoV-2 pandemic are still scarce. This case series of 33 PLWH patients with COVID-19 reveals symptoms and outcome in this special population. METHODS: Retrospective analysis of anonymized data including a...

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Autores principales: Härter, Georg, Spinner, Christoph D., Roider, Julia, Bickel, Markus, Krznaric, Ivanka, Grunwald, Stephan, Schabaz, Farhad, Gillor, Daniel, Postel, Nils, Mueller, Matthias C., Müller, Markus, Römer, Katja, Schewe, Knud, Hoffmann, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211976/
https://www.ncbi.nlm.nih.gov/pubmed/32394344
http://dx.doi.org/10.1007/s15010-020-01438-z
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author Härter, Georg
Spinner, Christoph D.
Roider, Julia
Bickel, Markus
Krznaric, Ivanka
Grunwald, Stephan
Schabaz, Farhad
Gillor, Daniel
Postel, Nils
Mueller, Matthias C.
Müller, Markus
Römer, Katja
Schewe, Knud
Hoffmann, Christian
author_facet Härter, Georg
Spinner, Christoph D.
Roider, Julia
Bickel, Markus
Krznaric, Ivanka
Grunwald, Stephan
Schabaz, Farhad
Gillor, Daniel
Postel, Nils
Mueller, Matthias C.
Müller, Markus
Römer, Katja
Schewe, Knud
Hoffmann, Christian
author_sort Härter, Georg
collection PubMed
description INTRODUCTION: Data on people living with human immunodeficiency virus (PLWH) in the current SARS-CoV-2 pandemic are still scarce. This case series of 33 PLWH patients with COVID-19 reveals symptoms and outcome in this special population. METHODS: Retrospective analysis of anonymized data including age, gender, HIV-associated parameters, symptoms, and outcome. RESULTS: Three out of 32 patients with documented outcomes died (9%). 91% of the patients recovered and 76% have been classified as mild cases. All patients were on antiretroviral treatment, of them 22 on tenofovir-containing regimen and 4 on the protease inhibitor darunavir. CONCLUSIONS: This preliminary case series does not support excess morbidity and mortality among symptomatic COVID-19 PLWH and with viral suppression on ART. SARS-CoV-2 infections may occur during boosted darunavir-based and/or on tenofovir-containing ART.
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spelling pubmed-72119762020-05-11 COVID-19 in people living with human immunodeficiency virus: a case series of 33 patients Härter, Georg Spinner, Christoph D. Roider, Julia Bickel, Markus Krznaric, Ivanka Grunwald, Stephan Schabaz, Farhad Gillor, Daniel Postel, Nils Mueller, Matthias C. Müller, Markus Römer, Katja Schewe, Knud Hoffmann, Christian Infection Original Paper INTRODUCTION: Data on people living with human immunodeficiency virus (PLWH) in the current SARS-CoV-2 pandemic are still scarce. This case series of 33 PLWH patients with COVID-19 reveals symptoms and outcome in this special population. METHODS: Retrospective analysis of anonymized data including age, gender, HIV-associated parameters, symptoms, and outcome. RESULTS: Three out of 32 patients with documented outcomes died (9%). 91% of the patients recovered and 76% have been classified as mild cases. All patients were on antiretroviral treatment, of them 22 on tenofovir-containing regimen and 4 on the protease inhibitor darunavir. CONCLUSIONS: This preliminary case series does not support excess morbidity and mortality among symptomatic COVID-19 PLWH and with viral suppression on ART. SARS-CoV-2 infections may occur during boosted darunavir-based and/or on tenofovir-containing ART. Springer Berlin Heidelberg 2020-05-11 2020 /pmc/articles/PMC7211976/ /pubmed/32394344 http://dx.doi.org/10.1007/s15010-020-01438-z Text en © Springer-Verlag GmbH Germany, part of Springer Nature 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Original Paper
Härter, Georg
Spinner, Christoph D.
Roider, Julia
Bickel, Markus
Krznaric, Ivanka
Grunwald, Stephan
Schabaz, Farhad
Gillor, Daniel
Postel, Nils
Mueller, Matthias C.
Müller, Markus
Römer, Katja
Schewe, Knud
Hoffmann, Christian
COVID-19 in people living with human immunodeficiency virus: a case series of 33 patients
title COVID-19 in people living with human immunodeficiency virus: a case series of 33 patients
title_full COVID-19 in people living with human immunodeficiency virus: a case series of 33 patients
title_fullStr COVID-19 in people living with human immunodeficiency virus: a case series of 33 patients
title_full_unstemmed COVID-19 in people living with human immunodeficiency virus: a case series of 33 patients
title_short COVID-19 in people living with human immunodeficiency virus: a case series of 33 patients
title_sort covid-19 in people living with human immunodeficiency virus: a case series of 33 patients
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211976/
https://www.ncbi.nlm.nih.gov/pubmed/32394344
http://dx.doi.org/10.1007/s15010-020-01438-z
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