Lis1 activates dynein motility by modulating its pairing with dynactin

Lissencephaly-1 (Lis1) is a key cofactor for dynein-mediated intracellular transport towards the minus-ends of microtubules (MTs). It remains unclear whether Lis1 serves as an inhibitor or an activator of mammalian dynein motility. Here we use single-molecule imaging and optical trapping to show tha...

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Detalles Bibliográficos
Autores principales: Elshenawy, Mohamed M., Kusakci, Emre, Volz, Sara, Baumbach, Janina, Bullock, Simon L., Yildiz, Ahmet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212015/
https://www.ncbi.nlm.nih.gov/pubmed/32341547
http://dx.doi.org/10.1038/s41556-020-0501-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212015/
https://www.ncbi.nlm.nih.gov/pubmed/32341547
http://dx.doi.org/10.1038/s41556-020-0501-4

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