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Exploiting differential Wnt target gene expression to generate a molecular biomarker for colorectal cancer stratification

OBJECTIVE: Pathological Wnt pathway activation is a conserved hallmark of colorectal cancer. Wnt-activating mutations can be divided into: i) ligand-independent (LI) alterations in intracellular signal transduction proteins (Adenomatous polyposis coli, β-catenin), causing constitutive pathway activa...

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Detalles Bibliográficos
Autores principales:	Kleeman, Sam O, Koelzer, Viktor H, Jones, Helen JS, Vazquez, Ester Gil, Davis, Hayley, East, James E, Arnold, Roland, Koppens, Martijn AJ, Blake, Andrew, Domingo, Enric, Cunningham, Chris, Beggs, Andrew D, Pestinger, Valerie, Loughrey, Maurice B, Wang, Lai-Mun, Lannagan, Tamsin RM, Woods, Susan L, Worthley, Daniel, Consortium, S:CORT, Tomlinson, Ian, Dunne, Philip D, Maughan, Timothy, Leedham, Simon J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2020
Materias:	Colon
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212029/ https://www.ncbi.nlm.nih.gov/pubmed/31563876 http://dx.doi.org/10.1136/gutjnl-2019-319126

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