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KDM4A regulates the maternal-to-zygotic transition by protecting broad H3K4me3 domains from H3K9me3 invasion in oocytes
The importance of germline-inherited posttranslational histone modifications on priming early mammalian development is just emerging(1–4). Histone H3 lysine 9 (H3K9) trimethylation is associated with heterochromatin and gene repression during cell-fate change(5), while histone H3 lysine 4 (H3K4) tri...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212036/ https://www.ncbi.nlm.nih.gov/pubmed/32231309 http://dx.doi.org/10.1038/s41556-020-0494-z |