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Amyloid precursor protein processing in human neurons with an allelic series of the PSEN1 intron 4 deletion mutation and total presenilin-1 knockout

Mutations in presenilin-1 (PSEN1), encoding the catalytic subunit of the amyloid precursor protein-processing enzyme γ-secretase, cause familial Alzheimer’s disease. However, the mechanism of disease is yet to be fully understood and it remains contentious whether mutations exert their effects predo...

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Detalles Bibliográficos
Autores principales:	Arber, Charles, Villegas-Llerena, Claudio, Toombs, Jamie, Pocock, Jennifer M, Ryan, Natalie S, Fox, Nick C, Zetterberg, Henrik, Hardy, John, Wray, Selina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212081/ https://www.ncbi.nlm.nih.gov/pubmed/32395715 http://dx.doi.org/10.1093/braincomms/fcz024

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