Cargando…

Developmental maturation of inhibitory control circuitry in a high-risk sample: A longitudinal fMRI study

BACKGROUND: The goal of this work was to characterize the maturation of inhibitory control brain function from childhood to early adulthood using longitudinal data collected in two cohorts. METHODS: Functional MRI during a go/no-go task was conducted in 290 participants, with 88 % undergoing repeate...

Descripción completa

Detalles Bibliográficos
Autores principales: Cope, Lora M., Hardee, Jillian E., Martz, Meghan E., Zucker, Robert A., Nichols, Thomas E., Heitzeg, Mary M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212183/
https://www.ncbi.nlm.nih.gov/pubmed/32510344
http://dx.doi.org/10.1016/j.dcn.2020.100781
_version_ 1783531571386515456
author Cope, Lora M.
Hardee, Jillian E.
Martz, Meghan E.
Zucker, Robert A.
Nichols, Thomas E.
Heitzeg, Mary M.
author_facet Cope, Lora M.
Hardee, Jillian E.
Martz, Meghan E.
Zucker, Robert A.
Nichols, Thomas E.
Heitzeg, Mary M.
author_sort Cope, Lora M.
collection PubMed
description BACKGROUND: The goal of this work was to characterize the maturation of inhibitory control brain function from childhood to early adulthood using longitudinal data collected in two cohorts. METHODS: Functional MRI during a go/no-go task was conducted in 290 participants, with 88 % undergoing repeated scanning at 1- to 2-year intervals. One group entered the study at age 7–13 years (n = 117); the other entered at age 18–23 years (n = 173). 33.1 % of the sample had two parents with a substance use disorder (SUD), 43.8 % had one parent with an SUD, and 23.1 % had no parents with an SUD. 1162 scans were completed, covering ages 7–28, with longitudinal data from the cohorts overlapping across ages 16–21. A marginal model with sandwich estimator standard errors was used to characterize voxel-wise age-related changes in hemodynamic response associated with successful inhibitory control. RESULTS: There was significant positive linear activation associated with age in the frontal, temporal, parietal, and occipital cortices. No clusters survived thresholding with negative linear, positive or negative quadratic, or positive or negative cubic contrasts. CONCLUSIONS: These findings extend previous cross-sectional and small-scale longitudinal studies that have observed positive linear developmental trajectories of brain function during inhibitory control.
format Online
Article
Text
id pubmed-7212183
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-72121832020-05-13 Developmental maturation of inhibitory control circuitry in a high-risk sample: A longitudinal fMRI study Cope, Lora M. Hardee, Jillian E. Martz, Meghan E. Zucker, Robert A. Nichols, Thomas E. Heitzeg, Mary M. Dev Cogn Neurosci Original Research BACKGROUND: The goal of this work was to characterize the maturation of inhibitory control brain function from childhood to early adulthood using longitudinal data collected in two cohorts. METHODS: Functional MRI during a go/no-go task was conducted in 290 participants, with 88 % undergoing repeated scanning at 1- to 2-year intervals. One group entered the study at age 7–13 years (n = 117); the other entered at age 18–23 years (n = 173). 33.1 % of the sample had two parents with a substance use disorder (SUD), 43.8 % had one parent with an SUD, and 23.1 % had no parents with an SUD. 1162 scans were completed, covering ages 7–28, with longitudinal data from the cohorts overlapping across ages 16–21. A marginal model with sandwich estimator standard errors was used to characterize voxel-wise age-related changes in hemodynamic response associated with successful inhibitory control. RESULTS: There was significant positive linear activation associated with age in the frontal, temporal, parietal, and occipital cortices. No clusters survived thresholding with negative linear, positive or negative quadratic, or positive or negative cubic contrasts. CONCLUSIONS: These findings extend previous cross-sectional and small-scale longitudinal studies that have observed positive linear developmental trajectories of brain function during inhibitory control. Elsevier 2020-04-25 /pmc/articles/PMC7212183/ /pubmed/32510344 http://dx.doi.org/10.1016/j.dcn.2020.100781 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Research
Cope, Lora M.
Hardee, Jillian E.
Martz, Meghan E.
Zucker, Robert A.
Nichols, Thomas E.
Heitzeg, Mary M.
Developmental maturation of inhibitory control circuitry in a high-risk sample: A longitudinal fMRI study
title Developmental maturation of inhibitory control circuitry in a high-risk sample: A longitudinal fMRI study
title_full Developmental maturation of inhibitory control circuitry in a high-risk sample: A longitudinal fMRI study
title_fullStr Developmental maturation of inhibitory control circuitry in a high-risk sample: A longitudinal fMRI study
title_full_unstemmed Developmental maturation of inhibitory control circuitry in a high-risk sample: A longitudinal fMRI study
title_short Developmental maturation of inhibitory control circuitry in a high-risk sample: A longitudinal fMRI study
title_sort developmental maturation of inhibitory control circuitry in a high-risk sample: a longitudinal fmri study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212183/
https://www.ncbi.nlm.nih.gov/pubmed/32510344
http://dx.doi.org/10.1016/j.dcn.2020.100781
work_keys_str_mv AT copeloram developmentalmaturationofinhibitorycontrolcircuitryinahighrisksamplealongitudinalfmristudy
AT hardeejilliane developmentalmaturationofinhibitorycontrolcircuitryinahighrisksamplealongitudinalfmristudy
AT martzmeghane developmentalmaturationofinhibitorycontrolcircuitryinahighrisksamplealongitudinalfmristudy
AT zuckerroberta developmentalmaturationofinhibitorycontrolcircuitryinahighrisksamplealongitudinalfmristudy
AT nicholsthomase developmentalmaturationofinhibitorycontrolcircuitryinahighrisksamplealongitudinalfmristudy
AT heitzegmarym developmentalmaturationofinhibitorycontrolcircuitryinahighrisksamplealongitudinalfmristudy