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Dynamic thiol and disulphide homoeostasis in fibromyalgia

INTRODUCTION: Thiol and disulphide levels are biomarkers that provide useful information about oxidative stress and antioxidant capacity, showing a different homoeostasis in inflammatory and proliferative diseases. We aimed to clarify the possible aetiology of this disease by using thiol and disulph...

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Autores principales: Karatas, Gulsah, Gunduz, Ramazan, Haskul, Ismail, Ustun, Betul, Neselioglu, Salim, Karatas, Fatih, Akyuz, Müfit, Erel, Ozcan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212223/
https://www.ncbi.nlm.nih.gov/pubmed/32399108
http://dx.doi.org/10.5114/aoms.2019.87052
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author Karatas, Gulsah
Gunduz, Ramazan
Haskul, Ismail
Ustun, Betul
Neselioglu, Salim
Karatas, Fatih
Akyuz, Müfit
Erel, Ozcan
author_facet Karatas, Gulsah
Gunduz, Ramazan
Haskul, Ismail
Ustun, Betul
Neselioglu, Salim
Karatas, Fatih
Akyuz, Müfit
Erel, Ozcan
author_sort Karatas, Gulsah
collection PubMed
description INTRODUCTION: Thiol and disulphide levels are biomarkers that provide useful information about oxidative stress and antioxidant capacity, showing a different homoeostasis in inflammatory and proliferative diseases. We aimed to clarify the possible aetiology of this disease by using thiol and disulphide levels in patients with fibromyalgia, the basis of which has not yet been clearly elucidated. MATERIAL AND METHODS: A total of 156 individuals: 86 patients with fibromyalgia and 70 age-matched controls were included in this prospective non-randomised case-control study. Demographic characteristics including smoking status, body mass index (BMI), the duration of complaints, and pain levels were carefully recorded. Dynamic thiol-disulphide homoeostasis in blood samples was determined by an automatic-spectrophotometric method. The Mann-Whitney U and Student’s t-test were used to determine the differences between the groups. RESULTS: Sex, BMI, and smoking status were similar between the groups (p = 0.62, p = 0.09, and p = 0.64, respectively). While native thiol levels were found to be high in patients with fibromyalgia (p = 0.018), disulphide levels and the rates of disulphide/native thiol and disulphide/total thiol were significantly low (p = 0.049, p = 0.007, and p = 0.007, respectively). Correlation analysis showed no significant relationship between thiol-disulphide levels and duration of complaints or pain level. CONCLUSIONS: Thiol-disulphide balance in fibromyalgia was found to be similar to benign proliferative diseases, suggesting that the underlying mechanism is more likely to be of proliferative pattern rather than inflammatory. Additionally, fibromyalgia is not directly associated with increase in oxidative stress. The molecular mechanisms need to be elucidated.
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spelling pubmed-72122232020-05-12 Dynamic thiol and disulphide homoeostasis in fibromyalgia Karatas, Gulsah Gunduz, Ramazan Haskul, Ismail Ustun, Betul Neselioglu, Salim Karatas, Fatih Akyuz, Müfit Erel, Ozcan Arch Med Sci Clinical Research INTRODUCTION: Thiol and disulphide levels are biomarkers that provide useful information about oxidative stress and antioxidant capacity, showing a different homoeostasis in inflammatory and proliferative diseases. We aimed to clarify the possible aetiology of this disease by using thiol and disulphide levels in patients with fibromyalgia, the basis of which has not yet been clearly elucidated. MATERIAL AND METHODS: A total of 156 individuals: 86 patients with fibromyalgia and 70 age-matched controls were included in this prospective non-randomised case-control study. Demographic characteristics including smoking status, body mass index (BMI), the duration of complaints, and pain levels were carefully recorded. Dynamic thiol-disulphide homoeostasis in blood samples was determined by an automatic-spectrophotometric method. The Mann-Whitney U and Student’s t-test were used to determine the differences between the groups. RESULTS: Sex, BMI, and smoking status were similar between the groups (p = 0.62, p = 0.09, and p = 0.64, respectively). While native thiol levels were found to be high in patients with fibromyalgia (p = 0.018), disulphide levels and the rates of disulphide/native thiol and disulphide/total thiol were significantly low (p = 0.049, p = 0.007, and p = 0.007, respectively). Correlation analysis showed no significant relationship between thiol-disulphide levels and duration of complaints or pain level. CONCLUSIONS: Thiol-disulphide balance in fibromyalgia was found to be similar to benign proliferative diseases, suggesting that the underlying mechanism is more likely to be of proliferative pattern rather than inflammatory. Additionally, fibromyalgia is not directly associated with increase in oxidative stress. The molecular mechanisms need to be elucidated. Termedia Publishing House 2019-08-15 /pmc/articles/PMC7212223/ /pubmed/32399108 http://dx.doi.org/10.5114/aoms.2019.87052 Text en Copyright: © 2019 Termedia & Banach http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Clinical Research
Karatas, Gulsah
Gunduz, Ramazan
Haskul, Ismail
Ustun, Betul
Neselioglu, Salim
Karatas, Fatih
Akyuz, Müfit
Erel, Ozcan
Dynamic thiol and disulphide homoeostasis in fibromyalgia
title Dynamic thiol and disulphide homoeostasis in fibromyalgia
title_full Dynamic thiol and disulphide homoeostasis in fibromyalgia
title_fullStr Dynamic thiol and disulphide homoeostasis in fibromyalgia
title_full_unstemmed Dynamic thiol and disulphide homoeostasis in fibromyalgia
title_short Dynamic thiol and disulphide homoeostasis in fibromyalgia
title_sort dynamic thiol and disulphide homoeostasis in fibromyalgia
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212223/
https://www.ncbi.nlm.nih.gov/pubmed/32399108
http://dx.doi.org/10.5114/aoms.2019.87052
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