Cargando…

Phase I Study in Healthy Women of a Novel Antimycotic Vaginal Ovule Combining Econazole and Benzydamine

PURPOSE: A novel fixed-dose combination of 150 mg of econazole with 6 mg of benzydamine formulated in vaginal ovules was investigated in a randomised, double-blind, four-parallel group, tolerability, and pharmacokinetic Phase I study in healthy women. METHODS: The fixed-dose combination was compared...

Descripción completa

Detalles Bibliográficos
Autores principales:	Di Stefano, A. F. D., Radicioni, M. M., Vaccani, A., Caccia, G., Focanti, F., Salvatori, E., Pelacchi, F., Picollo, R., Rosignoli, M. T., Olivieri, S., Bovi, G., Comandini, A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2020
Materias:	Clinical Study
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212273/ https://www.ncbi.nlm.nih.gov/pubmed/32410819 http://dx.doi.org/10.1155/2020/7201840

Ejemplares similares

Efficacy and Tolerability of Fitostimoline (Vaginal Cream, Ovules, and Vaginal Washing) and of Benzydamine Hydrochloride (Tantum Rosa Vaginal Cream and Vaginal Washing) in the Topical Treatment of Symptoms of Bacterial Vaginosis
por: Boselli, F., et al.
Publicado: (2012)

Effect of a food supplement containing berberine, monacolin K, hydroxytyrosol and coenzyme Q(10) on lipid levels: a randomized, double-blind, placebo controlled study
por: D’Addato, Sergio, et al.
Publicado: (2017)

The Benzydamine Experience: A Systematic Review of Benzydamine Abuse
por: Stefania, Chiappini, et al.
Publicado: (2021)

Comparative evaluation of rapidity of action of benzydamine hydrochloride 0.3% oromucosal spray and benzydamine hydrochloride 3 mg lozenges in patients with acute sore throat: A phase IV randomized trial
por: Valerio, Carmelina, et al.
Publicado: (2023)

Effect of 3 Single Doses of Trazodone on QTc Interval in Healthy Subjects
por: Tellone, Valeria, et al.
Publicado: (2020)

Effects of benzydamine and mouthwashes containing benzydamine on Candida albicans adhesion, biofilm formation, regrowth, and persistence
por: Ardizzoni, Andrea, et al.
Publicado: (2022)

Casein Micelles as Nanocarriers for Benzydamine Delivery
por: Zahariev, Nikolay, et al.
Publicado: (2021)

Structural mechanisms of TRPV6 inhibition by ruthenium red and econazole
por: Neuberger, Arthur, et al.
Publicado: (2021)

Antifungal Nail Lacquer for Enhanced Transungual Delivery of Econazole Nitrate
por: Puri, Vinam, et al.
Publicado: (2022)

The present and the future of benzydamine: expert opinion paper
por: Bossi, Paolo, et al.
Publicado: (2023)

Mucoadhesive Hydrogel Films of Econazole Nitrate: Formulation and Optimization Using Factorial Design
por: Gajra, Balaram, et al.
Publicado: (2014)

Formulation of Bilayer Benzydamine HCl Patch Targeted For Gingivitis
por: Sanghai, Piyush, et al.
Publicado: (2016)

The role of benzydamine in prevention and treatment of chemoradiotherapy-induced mucositis
por: Nicolatou-Galitis, Ourania, et al.
Publicado: (2021)

Casein Microgels as Benzydamine Hydrochloride Carriers for Prolonged Release
por: Milenkova, Sofia, et al.
Publicado: (2022)

Empirical versus preemptive antimycotic therapy in terms of outcome benefit
por: Milanov, S, et al.
Publicado: (2013)

Efficacy of moxifloxacin & econazole against multidrug resistant (MDR) Mycobacterium tuberculosis in murine model
por: Gupta, U.D., et al.
Publicado: (2015)

A NOTE ON ANTIMYCOTIC ACTIVITY OF MILK
por: Jain, Sudhir K
Publicado: (1993)

Efficacy and utility of a protocol for pre-emptive antimycotic therapy
por: Milanov, SG, et al.
Publicado: (2010)

Synergistic Activity of Econazole-Nitrate and Chelerythrine against Clinical Isolates of Candida albicans
por: Chen, Zhibao, et al.
Publicado: (2014)

Repurposing econazole as a pharmacological autophagy inhibitor to treat pancreatic ductal adenocarcinoma
por: Weng, Ningna, et al.
Publicado: (2022)

Acute Psychotic Symptoms due to Benzydamine Hydrochloride Abuse with Alcohol
por: Acar, Yahya Ayhan, et al.
Publicado: (2014)

Hallucinations after Ingesting a High Dose of Benzydamine Hydrochloride
por: Can, Burak, et al.
Publicado: (2016)

Comparison the Pain Relief of Amitriptyline Mouthwash with Benzydamine in Oral Mucositis
por: Kakoei, Shahla, et al.
Publicado: (2018)

Echinocandins: structural diversity, biosynthesis, and development of antimycotics
por: Hüttel, Wolfgang
Publicado: (2020)

In vivo active organometallic-containing antimycotic agents
por: Rubbiani, Riccardo, et al.
Publicado: (2021)

Econazole Nitrate Induces Apoptosis in MCF-7 Cells via Mitochondrial and Caspase Pathways
por: Sun, Juan, et al.
Publicado: (2014)

Benzydamine Oral Spray Inhibiting Parasympathetic Function of Tracheal Smooth Muscle
por: Wang, Hsing-Won, et al.
Publicado: (2015)

Efficacy of Clindamycin Vaginal Ovule (3-Day Treatment) vs. Clindamycin Vaginal Cream (7-Day Treatment) in Bacterial Vaginosis
por: Sobel, Jack, et al.
Publicado: (2001)

Clotrimazole, an Imidazole Antimycotic, Is a Potent Inhibitor of Angiogenesis
por: Takahashi, Hiroto, et al.
Publicado: (1998)

Vulvovaginal Candidiasis in Pregnancy—Between Sensitivity and Resistance to Antimycotics
por: Maftei, Nicoleta-Maricica, et al.
Publicado: (2023)

Econazole nitrate inhibits PI3K activity and promotes apoptosis in lung cancer cells
por: Dong, Chao, et al.
Publicado: (2017)

Econazole Induces p53-Dependent Apoptosis and Decreases Metastasis Ability in Gastric Cancer Cells
por: Choi, Eun Kyoung, et al.
Publicado: (2020)

Action of econazole on Ca(2+) levels and cytotoxicity in OC2 human oral cancer cells
por: Wang, Jue-Long, et al.
Publicado: (2023)

In vitro activity of econazole in comparison with three common antifungal agents against clinical Candida strains isolated from superficial infections
por: Abastabar, M, et al.
Publicado: (2015)

Benzydamine plays a role in limiting inflammatory pain induced by neuronal sensitization
por: Nikolaeva-Koleva, Magdalena, et al.
Publicado: (2023)

Antibacterial and Antimycotic Activity of Cotton Fabrics, Impregnated with Silver and Binary Silver/Copper Nanoparticles
por: Eremenko, A. M., et al.
Publicado: (2016)

Cervico-Vaginal Immunoglobulin G Levels Increase Post-Ovulation Independently of Neutrophils
por: Schaefer, Katrein, et al.
Publicado: (2014)

Enhanced Antifungal and Wound Healing Efficacy of Statistically Optimized, Physicochemically Evaluated Econazole-Triamcinolone Loaded Silica Nanoparticles
por: Maheen, Safirah, et al.
Publicado: (2022)

Mutations in the anti-sigma H factor RshA confer resistance to econazole and clotrimazole in Mycobacterium smegmatis
por: Morbidoni, Héctor R., et al.
Publicado: (2019)

Synergistic Antimicrobial Effect of Colistin in Combination with Econazole against Multidrug-Resistant Acinetobacter baumannii and Its Persisters
por: Xie, Miaomiao, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_0glj0n8v4nu4rp65i73vkbesmv