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Sonic Hedgehog Signaling Agonist (SAG) Triggers BDNF Secretion and Promotes the Maturation of GABAergic Networks in the Postnatal Rat Hippocampus
Sonic hedgehog (Shh) signaling plays critical roles during early central nervous system development, such as neural cell proliferation, patterning of the neural tube and neuronal differentiation. While Shh signaling is still present in the postnatal brain, the roles it may play are, however, largely...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212340/ https://www.ncbi.nlm.nih.gov/pubmed/32425757 http://dx.doi.org/10.3389/fncel.2020.00098 |
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author | Delmotte, Quentin Diabira, Diabe Belaidouni, Yasmine Hamze, Mira Kochmann, Marine Montheil, Aurélie Gaiarsa, Jean-Luc Porcher, Christophe Belgacem, Yesser H. |
author_facet | Delmotte, Quentin Diabira, Diabe Belaidouni, Yasmine Hamze, Mira Kochmann, Marine Montheil, Aurélie Gaiarsa, Jean-Luc Porcher, Christophe Belgacem, Yesser H. |
author_sort | Delmotte, Quentin |
collection | PubMed |
description | Sonic hedgehog (Shh) signaling plays critical roles during early central nervous system development, such as neural cell proliferation, patterning of the neural tube and neuronal differentiation. While Shh signaling is still present in the postnatal brain, the roles it may play are, however, largely unknown. In particular, Shh signaling components are found at the synaptic junction in the maturing hippocampus during the first two postnatal weeks. This period is characterized by the presence of ongoing spontaneous synaptic activity at the cellular and network levels thought to play important roles in the onset of neuronal circuit formation and synaptic plasticity. Here, we demonstrate that non-canonical Shh signaling increases the frequency of the synchronized electrical activity called Giant Depolarizing Potentials (GDP) and enhances spontaneous GABA post-synaptic currents in the rodent hippocampus during the early postnatal period. This effect is mediated specifically through the Shh co-receptor Smoothened via intracellular Ca(2+) signal and the activation of the BDNF-TrkB signaling pathway. Given the importance of these spontaneous events on neuronal network maturation and refinement, this study opens new perspectives for Shh signaling on the control of early stages of postnatal brain maturation and physiology. |
format | Online Article Text |
id | pubmed-7212340 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-72123402020-05-18 Sonic Hedgehog Signaling Agonist (SAG) Triggers BDNF Secretion and Promotes the Maturation of GABAergic Networks in the Postnatal Rat Hippocampus Delmotte, Quentin Diabira, Diabe Belaidouni, Yasmine Hamze, Mira Kochmann, Marine Montheil, Aurélie Gaiarsa, Jean-Luc Porcher, Christophe Belgacem, Yesser H. Front Cell Neurosci Cellular Neuroscience Sonic hedgehog (Shh) signaling plays critical roles during early central nervous system development, such as neural cell proliferation, patterning of the neural tube and neuronal differentiation. While Shh signaling is still present in the postnatal brain, the roles it may play are, however, largely unknown. In particular, Shh signaling components are found at the synaptic junction in the maturing hippocampus during the first two postnatal weeks. This period is characterized by the presence of ongoing spontaneous synaptic activity at the cellular and network levels thought to play important roles in the onset of neuronal circuit formation and synaptic plasticity. Here, we demonstrate that non-canonical Shh signaling increases the frequency of the synchronized electrical activity called Giant Depolarizing Potentials (GDP) and enhances spontaneous GABA post-synaptic currents in the rodent hippocampus during the early postnatal period. This effect is mediated specifically through the Shh co-receptor Smoothened via intracellular Ca(2+) signal and the activation of the BDNF-TrkB signaling pathway. Given the importance of these spontaneous events on neuronal network maturation and refinement, this study opens new perspectives for Shh signaling on the control of early stages of postnatal brain maturation and physiology. Frontiers Media S.A. 2020-04-23 /pmc/articles/PMC7212340/ /pubmed/32425757 http://dx.doi.org/10.3389/fncel.2020.00098 Text en Copyright © 2020 Delmotte, Diabira, Belaidouni, Hamze, Kochmann, Montheil, Gaiarsa, Porcher and Belgacem. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cellular Neuroscience Delmotte, Quentin Diabira, Diabe Belaidouni, Yasmine Hamze, Mira Kochmann, Marine Montheil, Aurélie Gaiarsa, Jean-Luc Porcher, Christophe Belgacem, Yesser H. Sonic Hedgehog Signaling Agonist (SAG) Triggers BDNF Secretion and Promotes the Maturation of GABAergic Networks in the Postnatal Rat Hippocampus |
title | Sonic Hedgehog Signaling Agonist (SAG) Triggers BDNF Secretion and Promotes the Maturation of GABAergic Networks in the Postnatal Rat Hippocampus |
title_full | Sonic Hedgehog Signaling Agonist (SAG) Triggers BDNF Secretion and Promotes the Maturation of GABAergic Networks in the Postnatal Rat Hippocampus |
title_fullStr | Sonic Hedgehog Signaling Agonist (SAG) Triggers BDNF Secretion and Promotes the Maturation of GABAergic Networks in the Postnatal Rat Hippocampus |
title_full_unstemmed | Sonic Hedgehog Signaling Agonist (SAG) Triggers BDNF Secretion and Promotes the Maturation of GABAergic Networks in the Postnatal Rat Hippocampus |
title_short | Sonic Hedgehog Signaling Agonist (SAG) Triggers BDNF Secretion and Promotes the Maturation of GABAergic Networks in the Postnatal Rat Hippocampus |
title_sort | sonic hedgehog signaling agonist (sag) triggers bdnf secretion and promotes the maturation of gabaergic networks in the postnatal rat hippocampus |
topic | Cellular Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212340/ https://www.ncbi.nlm.nih.gov/pubmed/32425757 http://dx.doi.org/10.3389/fncel.2020.00098 |
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