Sex differences in redox homeostasis in renal disease

Sex differences in redox signaling in the kidney present new challenges and opportunities for understanding the physiology and pathophysiology of the kidney. This review will focus on reactive oxygen species, immune-related signaling pathways and endothelin-1 as potential mediators of sex-difference...

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Detalles Bibliográficos
Autores principales: Mitchell, Tanecia, De Miguel, Carmen, Gohar, Eman Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212488/
https://www.ncbi.nlm.nih.gov/pubmed/32197946
http://dx.doi.org/10.1016/j.redox.2020.101489
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author Mitchell, Tanecia
De Miguel, Carmen
Gohar, Eman Y.
author_facet Mitchell, Tanecia
De Miguel, Carmen
Gohar, Eman Y.
author_sort Mitchell, Tanecia
collection PubMed
description Sex differences in redox signaling in the kidney present new challenges and opportunities for understanding the physiology and pathophysiology of the kidney. This review will focus on reactive oxygen species, immune-related signaling pathways and endothelin-1 as potential mediators of sex-differences in redox homeostasis in the kidney. Additionally, this review will highlight male-female differences in redox signaling in several major cardiovascular and renal disorders namely acute kidney injury, diabetic nephropathy, kidney stone disease and salt-sensitive hypertension. Furthermore, we will discuss the contribution of redox signaling in the pathogenesis of postmenopausal hypertension and preeclampsia.
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spelling pubmed-72124882020-05-13 Sex differences in redox homeostasis in renal disease Mitchell, Tanecia De Miguel, Carmen Gohar, Eman Y. Redox Biol Article Sex differences in redox signaling in the kidney present new challenges and opportunities for understanding the physiology and pathophysiology of the kidney. This review will focus on reactive oxygen species, immune-related signaling pathways and endothelin-1 as potential mediators of sex-differences in redox homeostasis in the kidney. Additionally, this review will highlight male-female differences in redox signaling in several major cardiovascular and renal disorders namely acute kidney injury, diabetic nephropathy, kidney stone disease and salt-sensitive hypertension. Furthermore, we will discuss the contribution of redox signaling in the pathogenesis of postmenopausal hypertension and preeclampsia. Elsevier 2020-03-09 /pmc/articles/PMC7212488/ /pubmed/32197946 http://dx.doi.org/10.1016/j.redox.2020.101489 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Mitchell, Tanecia
De Miguel, Carmen
Gohar, Eman Y.
Sex differences in redox homeostasis in renal disease
title Sex differences in redox homeostasis in renal disease
title_full Sex differences in redox homeostasis in renal disease
title_fullStr Sex differences in redox homeostasis in renal disease
title_full_unstemmed Sex differences in redox homeostasis in renal disease
title_short Sex differences in redox homeostasis in renal disease
title_sort sex differences in redox homeostasis in renal disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212488/
https://www.ncbi.nlm.nih.gov/pubmed/32197946
http://dx.doi.org/10.1016/j.redox.2020.101489
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