Chromatin topology reorganization and transcription repression by PML-RARα in acute promyeloid leukemia

BACKGROUND: Acute promyeloid leukemia (APL) is characterized by the oncogenic fusion protein PML-RARα, a major etiological agent in APL. However, the molecular mechanisms underlying the role of PML-RARα in leukemogenesis remain largely unknown. RESULTS: Using an inducible system, we comprehensively...

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Detalles Bibliográficos
Autores principales: Wang, Ping, Tang, Zhonghui, Lee, Byoungkoo, Zhu, Jacqueline Jufen, Cai, Liuyang, Szalaj, Przemyslaw, Tian, Simon Zhongyuan, Zheng, Meizhen, Plewczynski, Dariusz, Ruan, Xiaoan, Liu, Edison T., Wei, Chia-Lin, Ruan, Yijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212609/
https://www.ncbi.nlm.nih.gov/pubmed/32393309
http://dx.doi.org/10.1186/s13059-020-02030-2

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