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Phase I trial of dimethyl fumarate, temozolomide, and radiation therapy in glioblastoma

BACKGROUND: Dimethyl fumarate (DMF), an oral agent approved for the treatment of relapsing–remitting multiple sclerosis (RRMS), has promising preclinical activity against glioblastoma (GBM). This phase I study sought to determine the recommended phase 2 dose (RP2D) of DMF and evaluate its safety and...

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Detalles Bibliográficos
Autores principales:	Shafer, Danielle, Tombes, Mary Beth, Shrader, Ellen, Ryan, Alison, Bandyopadhyay, Dipankar, Dent, Paul, Malkin, Mark
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Clinical Investigations
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212848/ https://www.ncbi.nlm.nih.gov/pubmed/32642720 http://dx.doi.org/10.1093/noajnl/vdz052

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