TP53, ATRX alterations, and low tumor mutation load feature IDH-wildtype giant cell glioblastoma despite exceptional ultra-mutated tumors

BACKGROUND: Giant cell glioblastoma (gcGBM) is a rare morphological variant of IDH-wildtype (IDHwt) GBM that occurs in young adults and have a slightly better prognosis than “classic” IDHwt GBM. METHODS: We studied 36 GBMs, 14 with a histopathological diagnosis of gcGBM and 22 with a giant cell comp...

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Detalles Bibliográficos
Autores principales: Cantero, Diana, Mollejo, Manuela, Sepúlveda, Juan M, D’Haene, Nicky, Gutiérrez-Guamán, Myriam J, Rodríguez de Lope, Ángel, Fiaño, Concepción, Castresana, Javier S, Lebrun, Laetitia, Rey, Juan A, Salmon, Isabelle, Meléndez, Bárbara, Hernández-Laín, Aurelio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Basic and Translational Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212869/
https://www.ncbi.nlm.nih.gov/pubmed/32642724
http://dx.doi.org/10.1093/noajnl/vdz059

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