Preclinical and clinical investigation of intratumoral chemotherapy pharmacokinetics in DIPG using gemcitabine

BACKGROUND: Hundreds of systemic chemotherapy trials in diffuse intrinsic pontine glioma (DIPG) have not improved survival, potentially due to lack of intratumoral penetration, which has not previously been assessed in humans. METHODS: We used gemcitabine as a model agent to assess DIPG intratumoral...

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Detalles Bibliográficos
Autores principales: Green, Adam L, Flannery, Patrick, Hankinson, Todd C, O’Neill, Brent, Amani, Vladimir, DeSisto, John, Knox, Aaron, Chatwin, Hannah, Lemma, Rakeb, Hoffman, Lindsey M, Mulcahy Levy, Jean, Raybin, Jennifer, Hemenway, Molly, Gilani, Ahmed, Koschmann, Carl, Dahl, Nathan, Handler, Michael, Pierce, Angela, Venkataraman, Sujatha, Foreman, Nicholas, Vibhakar, Rajeev, Wempe, Michael F, Dorris, Kathleen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Basic and Translational Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212907/
https://www.ncbi.nlm.nih.gov/pubmed/32642682
http://dx.doi.org/10.1093/noajnl/vdaa021

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