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Combined targeting of PI3K and MEK effector pathways via CED for DIPG therapy

BACKGROUND: Midline gliomas like diffuse intrinsic pontine glioma (DIPG) carry poor prognosis and lack effective treatment options. Studies have implicated amplifications in the phosphatidylinositol 3-kinase (PI3K) signaling pathway in tumorigenesis; compensatory activation of parallel pathways (eg,...

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Detalles Bibliográficos
Autores principales:	Chang, Raymond, Tosi, Umberto, Voronina, Julia, Adeuyan, Oluwaseyi, Wu, Linda Y, Schweitzer, Melanie E, Pisapia, David J, Becher, Oren J, Souweidane, Mark M, Maachani, Uday B
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Basic and Translational Investigations
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212917/ https://www.ncbi.nlm.nih.gov/pubmed/32642647 http://dx.doi.org/10.1093/noajnl/vdz004

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