The soluble form of pan-RTK inhibitor and tumor suppressor LRIG1 mediates downregulation of AXL through direct protein–protein interaction in glioblastoma

BACKGROUND: Targeted approaches for inhibiting epidermal growth factor receptor (EGFR) and other receptor tyrosine kinases (RTKs) in glioblastoma (GBM) have led to therapeutic resistance and little clinical benefit, raising the need for the development of alternative strategies. Endogenous LRIG1 (Le...

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Detalles Bibliográficos
Autores principales: Neirinckx, Virginie, Hau, Ann-Christin, Schuster, Anne, Fritah, Sabrina, Tiemann, Katja, Klein, Eliane, Nazarov, Petr V, Matagne, André, Szpakowska, Martyna, Meyrath, Max, Chevigné, Andy, Schmidt, Mirko H H, Niclou, Simone P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Basic and Translational Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212925/
https://www.ncbi.nlm.nih.gov/pubmed/32642659
http://dx.doi.org/10.1093/noajnl/vdz024

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