BOT-02 2-METHYLTHIO MODIFICATION OF N6-ISOPENTENYLADENOSINE IN MITOCHONDRIAL TRNAS BY CDK5RAP1 PROMOTES THE MAINTENANCE OF GLIOMA-INITIATING CELLS

2-Methylthio-N(6)-isopentenyl modification of adenosine (ms(2)i(6)A) is an evolutionally conserved modification that is found in mitochondrial (mt)-tRNAs. Cdk5 regulatory subunit-associated protein 1 (CDK5RAP1) specifically converts N6-isopentenyladenosine (i(6)A) to ms(2)i(6)A at position A37 of fo...

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Detalles Bibliográficos
Autores principales: Yamamoto, Takahiro, Fujimura, Atsushi, Fan-Yan, Wei, Kai, Keitarou, Takezaki, Tatsuya, Ohta, Kazutaka, Kuroda, Jun-Ichirou, Shinojima, Naoki, Tomizawa, Kazuhito, Mukasa, Akitake
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213080/
http://dx.doi.org/10.1093/noajnl/vdz039.054

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