THER-11. PEPTIDE-MEDIATED PERMEABILIZATION OF THE BLOOD-BRAIN BARRIER IMPROVES DRUG DELIVERY TO BRAIN METASTASIS

BACKGROUND: Melanoma patients have a high risk of developing brain metastases, which is associated with a poor prognosis. The blood-brain barrier (BBB) inhibits sufficient drug delivery into metastatic lesions. We investigated the ability of a synthetic peptide (K16ApoE) to permeabilize the BBB for...

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Detalles Bibliográficos
Autores principales: Aasen, Synnøve Nymark, Espedal, Heidi, Holte, Christopher, Keunen, Olivier, Karlsen, Tine Veronika, Tenstad, Olav, Maherally, Zaynah, Miletic, Hrvoje, Hoang, Tuyen, Eikeland, Anne Vaag, Baghirov, Habib, Olberg, Dag Erlend, Pilkington, Geoffrey J, Sarkar, Gobinda, Jenkins, Robert, Sundstrøm, Terje, Bjerkvig, Rolf, Thorsen, Frits
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213147/
http://dx.doi.org/10.1093/noajnl/vdz014.054

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