MLTI-15. A CASE SERIES OF PRE-OPERATIVE GAMMA-KNIFE RADIOSURGERY FOR RESECTABLE BRAIN METASTASES

Recent advances in the systemic treatment of various cancers have resulted in longer survival and higher incidence of brain metastases. Phase 3 trials in north America and in Japan have demonstrated that stereotactic radiosurgery will be a standard adjuvant modality following surgery for resectable...

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Autores principales: Takezaki, Tatsuya, Yamamoto, Haruaki, Shinojima, Naoki, Kuroda, Jun-ichiro, Yamashiro, Shigeo, Mukasa, Akitake
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213151/
http://dx.doi.org/10.1093/noajnl/vdz014.074
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author Takezaki, Tatsuya
Yamamoto, Haruaki
Shinojima, Naoki
Kuroda, Jun-ichiro
Yamashiro, Shigeo
Mukasa, Akitake
author_facet Takezaki, Tatsuya
Yamamoto, Haruaki
Shinojima, Naoki
Kuroda, Jun-ichiro
Yamashiro, Shigeo
Mukasa, Akitake
author_sort Takezaki, Tatsuya
collection PubMed
description Recent advances in the systemic treatment of various cancers have resulted in longer survival and higher incidence of brain metastases. Phase 3 trials in north America and in Japan have demonstrated that stereotactic radiosurgery will be a standard adjuvant modality following surgery for resectable brain metastases. However, we don’t know the optimal sequence of this combination therapy. We hypothesized that pre-operative stereotactic radiosurgery for resectable brain metastases provides favorable rates of local control, overall survival, leptomeningeal dissemination and symptomatic radiation necrosis. We have experienced 4 cases of resected brain metastases within 1–7 days after Gamma-knife surgery (median margin dose:22Gy) and have been following their clinical course. We will show the repressive cases.
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spelling pubmed-72131512020-07-07 MLTI-15. A CASE SERIES OF PRE-OPERATIVE GAMMA-KNIFE RADIOSURGERY FOR RESECTABLE BRAIN METASTASES Takezaki, Tatsuya Yamamoto, Haruaki Shinojima, Naoki Kuroda, Jun-ichiro Yamashiro, Shigeo Mukasa, Akitake Neurooncol Adv Abstracts Recent advances in the systemic treatment of various cancers have resulted in longer survival and higher incidence of brain metastases. Phase 3 trials in north America and in Japan have demonstrated that stereotactic radiosurgery will be a standard adjuvant modality following surgery for resectable brain metastases. However, we don’t know the optimal sequence of this combination therapy. We hypothesized that pre-operative stereotactic radiosurgery for resectable brain metastases provides favorable rates of local control, overall survival, leptomeningeal dissemination and symptomatic radiation necrosis. We have experienced 4 cases of resected brain metastases within 1–7 days after Gamma-knife surgery (median margin dose:22Gy) and have been following their clinical course. We will show the repressive cases. Oxford University Press 2019-08-12 /pmc/articles/PMC7213151/ http://dx.doi.org/10.1093/noajnl/vdz014.074 Text en © The Author(s) 2019. Published by Oxford University Press, the Society for Neuro-Oncology and the European Association of Neuro-Oncology. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Abstracts
Takezaki, Tatsuya
Yamamoto, Haruaki
Shinojima, Naoki
Kuroda, Jun-ichiro
Yamashiro, Shigeo
Mukasa, Akitake
MLTI-15. A CASE SERIES OF PRE-OPERATIVE GAMMA-KNIFE RADIOSURGERY FOR RESECTABLE BRAIN METASTASES
title MLTI-15. A CASE SERIES OF PRE-OPERATIVE GAMMA-KNIFE RADIOSURGERY FOR RESECTABLE BRAIN METASTASES
title_full MLTI-15. A CASE SERIES OF PRE-OPERATIVE GAMMA-KNIFE RADIOSURGERY FOR RESECTABLE BRAIN METASTASES
title_fullStr MLTI-15. A CASE SERIES OF PRE-OPERATIVE GAMMA-KNIFE RADIOSURGERY FOR RESECTABLE BRAIN METASTASES
title_full_unstemmed MLTI-15. A CASE SERIES OF PRE-OPERATIVE GAMMA-KNIFE RADIOSURGERY FOR RESECTABLE BRAIN METASTASES
title_short MLTI-15. A CASE SERIES OF PRE-OPERATIVE GAMMA-KNIFE RADIOSURGERY FOR RESECTABLE BRAIN METASTASES
title_sort mlti-15. a case series of pre-operative gamma-knife radiosurgery for resectable brain metastases
topic Abstracts
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213151/
http://dx.doi.org/10.1093/noajnl/vdz014.074
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