TRLS-08. CNS PENETRATION AND PRELIMINARY EFFICACY OF SACUTIZUMAB GOVITECAN IN BREAST BRAIN METASTASIS AND GLIOBLASTOMA: A SURGICAL STUDY

Sacituzumab govitecan (SG) is an antibody drug conjugate (ADC) that targets Trop-2 for the selective delivery of SN-38 to tumors. SG carries SN-38, a topoisomerase inhibitor active in the nanomolar range for most cells (including TNBC and GBM) and freely cross the blood brain barrier. SN-38 is conju...

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Detalles Bibliográficos
Autores principales: Brenner, Andrew, Floyd, John, Surapaneni, Prathiba, Madhusudanan-Kunnuparampil, Vinu, Tiziani, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213261/
http://dx.doi.org/10.1093/noajnl/vdz014.041

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213261/
http://dx.doi.org/10.1093/noajnl/vdz014.041

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