THER-12. PRECLINICAL EVALUATION OF NERATINIB PLUS T-DM1 IN ORTHOTOPIC PDX MODELS OF HER2-POSITIVE BREAST CANCER BRAIN METASTASES

Breast cancer brain metastases (BCBM) are a major cause of morbidity and mortality, despite multimodal management including surgery, radiotherapy, and systemic therapies. There is an urgent need to develop novel, efficacious alternatives. Neratinib is an orally bioavailable, irreversible pan-HER tyr...

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Detalles Bibliográficos
Autores principales: Ni, Jing, Wang, Yanzhi, Diala, Irmina, Kabraji, Sheheryar, Freedman, Rachel, Lin, Nancy, Zhao, Jean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213268/
http://dx.doi.org/10.1093/noajnl/vdz014.055

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