TB-06 MOLECULAR MECHANISM OF BRAIN TUMOUR FORMATION DRIVEN BY SUPRATENTORIAL EPENDYMOMA-SPECIFIC YAP1 FUSION GENES

YAP1 fusion-positive supratentorial ependymomas predominantly occur in infants, but the molecular mechanisms of oncogenesis are unknown. Here we show YAP1-MAMLD1 fusions but not YAP1 wildtype are sufficient to drive malignant transformation of neural progenitors in the developing cerebral cortex in...

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Detalles Bibliográficos
Autores principales: Kawauchi, Daisuke, Pajtler, Kristian, Wei, Yiju, Okonechnikov, Konstantin, Silva, Patricia, Jones, David, Hoshino, Mikio, Pfister, Stefan, Kool, Marcel, Li, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213335/
http://dx.doi.org/10.1093/noajnl/vdz039.048

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