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Increased Expression of EZH2 Is Mediated by Higher Glycolysis and mTORC1 Activation in Lupus CD4(+) T Cells
OBJECTIVE: EZH2 is overexpressed in CD4(+) T cells from patients with systemic lupus erythematosus (SLE). Increased disease activity in SLE patients is associated with a proinflammatory epigenetic shift in naïve CD4(+) T cells, likely mediated by EZH2. Here we aim to understand the upstream mechanis...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213603/ https://www.ncbi.nlm.nih.gov/pubmed/32395334 http://dx.doi.org/10.20900/immunometab20200013 |