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Psychological Symptoms and Quality of Life After Simultaneous Kidney and Pancreas Transplantation

Patients that have undergone successful simultaneous pancreas/kidney (SPK) transplantation attain normoglycemia and are free from dialysis. However, only a minor improvement in quality of life (QOL) has been demonstrated. Here, we evaluated the role of psychological symptoms in QOL after SPK transpl...

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Autores principales: Nijhoff, Michiel F., Hovens, Jacqueline G.F.M., Huisman, Sasja D., Ringers, Jan, Rabelink, Ton A.J., de Fijter, Hans J.W., van der Boog, Paul J.M., de Koning, Eelco J.P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213608/
https://www.ncbi.nlm.nih.gov/pubmed/32548246
http://dx.doi.org/10.1097/TXD.0000000000000996
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author Nijhoff, Michiel F.
Hovens, Jacqueline G.F.M.
Huisman, Sasja D.
Ringers, Jan
Rabelink, Ton A.J.
de Fijter, Hans J.W.
van der Boog, Paul J.M.
de Koning, Eelco J.P.
author_facet Nijhoff, Michiel F.
Hovens, Jacqueline G.F.M.
Huisman, Sasja D.
Ringers, Jan
Rabelink, Ton A.J.
de Fijter, Hans J.W.
van der Boog, Paul J.M.
de Koning, Eelco J.P.
author_sort Nijhoff, Michiel F.
collection PubMed
description Patients that have undergone successful simultaneous pancreas/kidney (SPK) transplantation attain normoglycemia and are free from dialysis. However, only a minor improvement in quality of life (QOL) has been demonstrated. Here, we evaluated the role of psychological symptoms in QOL after SPK transplantation. METHODS. We assessed patients with type 1 diabetes and end-stage renal disease waitlisted for SPK transplantation (pre-SPK, n = 47), and recipients of an SPK transplant (post-SPK, n = 72). Matched patients with type 1 diabetes without end-stage renal disease were included as reference group (type 1 diabetes [T1D] reference group, n = 42). The brief symptom inventory (BSI) was used to measure psychological symptoms. The Short Form-36 (SF-36) was used to determine QOL. RESULTS. Post-SPK patients scored slightly better on the SF-36 than pre-SPK patients (“General health” 47.2 ± 23.1 versus 37.5 ± 18.1 [P = 0.017]). In the T1D reference group, this score was 60.6 ± 22.3. Post- and pre-SPK patients had similar BSI scores (0.54 ± 0.55 and 0.45 ± 0.42, respectively [P = 0.34]). This score was better in the T1D reference group (BSI score 0.32 ± 0.33). The BSI score inversely correlated with the SF-36 (r = −0.61, P < 0.001). CONCLUSIONS. Psychological symptoms are prevalent in both pre-SPK and post-SPK patients and could play an important role in the reduced QOL observed in these groups.
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spelling pubmed-72136082020-06-15 Psychological Symptoms and Quality of Life After Simultaneous Kidney and Pancreas Transplantation Nijhoff, Michiel F. Hovens, Jacqueline G.F.M. Huisman, Sasja D. Ringers, Jan Rabelink, Ton A.J. de Fijter, Hans J.W. van der Boog, Paul J.M. de Koning, Eelco J.P. Transplant Direct Pancreas and Islet Transplantation Patients that have undergone successful simultaneous pancreas/kidney (SPK) transplantation attain normoglycemia and are free from dialysis. However, only a minor improvement in quality of life (QOL) has been demonstrated. Here, we evaluated the role of psychological symptoms in QOL after SPK transplantation. METHODS. We assessed patients with type 1 diabetes and end-stage renal disease waitlisted for SPK transplantation (pre-SPK, n = 47), and recipients of an SPK transplant (post-SPK, n = 72). Matched patients with type 1 diabetes without end-stage renal disease were included as reference group (type 1 diabetes [T1D] reference group, n = 42). The brief symptom inventory (BSI) was used to measure psychological symptoms. The Short Form-36 (SF-36) was used to determine QOL. RESULTS. Post-SPK patients scored slightly better on the SF-36 than pre-SPK patients (“General health” 47.2 ± 23.1 versus 37.5 ± 18.1 [P = 0.017]). In the T1D reference group, this score was 60.6 ± 22.3. Post- and pre-SPK patients had similar BSI scores (0.54 ± 0.55 and 0.45 ± 0.42, respectively [P = 0.34]). This score was better in the T1D reference group (BSI score 0.32 ± 0.33). The BSI score inversely correlated with the SF-36 (r = −0.61, P < 0.001). CONCLUSIONS. Psychological symptoms are prevalent in both pre-SPK and post-SPK patients and could play an important role in the reduced QOL observed in these groups. Wolters Kluwer Health 2020-04-27 /pmc/articles/PMC7213608/ /pubmed/32548246 http://dx.doi.org/10.1097/TXD.0000000000000996 Text en Copyright © 2020 The Author(s). Transplantation Direct. Published by Wolters Kluwer Health, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Pancreas and Islet Transplantation
Nijhoff, Michiel F.
Hovens, Jacqueline G.F.M.
Huisman, Sasja D.
Ringers, Jan
Rabelink, Ton A.J.
de Fijter, Hans J.W.
van der Boog, Paul J.M.
de Koning, Eelco J.P.
Psychological Symptoms and Quality of Life After Simultaneous Kidney and Pancreas Transplantation
title Psychological Symptoms and Quality of Life After Simultaneous Kidney and Pancreas Transplantation
title_full Psychological Symptoms and Quality of Life After Simultaneous Kidney and Pancreas Transplantation
title_fullStr Psychological Symptoms and Quality of Life After Simultaneous Kidney and Pancreas Transplantation
title_full_unstemmed Psychological Symptoms and Quality of Life After Simultaneous Kidney and Pancreas Transplantation
title_short Psychological Symptoms and Quality of Life After Simultaneous Kidney and Pancreas Transplantation
title_sort psychological symptoms and quality of life after simultaneous kidney and pancreas transplantation
topic Pancreas and Islet Transplantation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213608/
https://www.ncbi.nlm.nih.gov/pubmed/32548246
http://dx.doi.org/10.1097/TXD.0000000000000996
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