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Model based estimation of QT intervals in non-invasive fetal ECG signals
The end timing of T waves in fetal electrocardiogram (fECG) is important for the evaluation of ST and QT intervals which are vital markers to assess cardiac repolarization patterns. Monitoring malignant fetal arrhythmias in utero is fundamental to care in congenital heart anomalies preventing perina...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213701/ https://www.ncbi.nlm.nih.gov/pubmed/32392232 http://dx.doi.org/10.1371/journal.pone.0232769 |
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author | Widatalla, Namareq Kasahara, Yoshiyuki Kimura, Yoshitaka Khandoker, Ahsan |
author_facet | Widatalla, Namareq Kasahara, Yoshiyuki Kimura, Yoshitaka Khandoker, Ahsan |
author_sort | Widatalla, Namareq |
collection | PubMed |
description | The end timing of T waves in fetal electrocardiogram (fECG) is important for the evaluation of ST and QT intervals which are vital markers to assess cardiac repolarization patterns. Monitoring malignant fetal arrhythmias in utero is fundamental to care in congenital heart anomalies preventing perinatal death. Currently, reliable detection of end of T waves is possible only by using fetal scalp ECG (fsECG) and fetal magnetocardiography (fMCG). fMCG is expensive and less accessible and fsECG is an invasive technique available only during intrapartum period. Another safer and affordable alternative is the non-invasive fECG (nfECG) which can provide similar assessment provided by fsECG and fMECG but with less accuracy (not beat by beat). Detection of T waves using nfECG is challenging because of their low amplitudes and high noise. In this study, a novel model-based method that estimates the end of T waves in nfECG signals is proposed. The repolarization phase has been modeled as the discharging phase of a capacitor. To test the model, fECG signals were collected from 58 pregnant women (age: (34 ± 6) years old) bearing normal and abnormal fetuses with gestational age (GA) 20-41 weeks. QT and QTc intervals have been calculated to test the level of agreement between the model-based and reference values (fsECG and Doppler Ultrasound (DUS) signals) in normal subjects. The results of the test showed high agreement between model-based and reference values (difference < 5%), which implies that the proposed model could be an alternative method to detect the end of T waves in nfECG signals. |
format | Online Article Text |
id | pubmed-7213701 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-72137012020-05-26 Model based estimation of QT intervals in non-invasive fetal ECG signals Widatalla, Namareq Kasahara, Yoshiyuki Kimura, Yoshitaka Khandoker, Ahsan PLoS One Research Article The end timing of T waves in fetal electrocardiogram (fECG) is important for the evaluation of ST and QT intervals which are vital markers to assess cardiac repolarization patterns. Monitoring malignant fetal arrhythmias in utero is fundamental to care in congenital heart anomalies preventing perinatal death. Currently, reliable detection of end of T waves is possible only by using fetal scalp ECG (fsECG) and fetal magnetocardiography (fMCG). fMCG is expensive and less accessible and fsECG is an invasive technique available only during intrapartum period. Another safer and affordable alternative is the non-invasive fECG (nfECG) which can provide similar assessment provided by fsECG and fMECG but with less accuracy (not beat by beat). Detection of T waves using nfECG is challenging because of their low amplitudes and high noise. In this study, a novel model-based method that estimates the end of T waves in nfECG signals is proposed. The repolarization phase has been modeled as the discharging phase of a capacitor. To test the model, fECG signals were collected from 58 pregnant women (age: (34 ± 6) years old) bearing normal and abnormal fetuses with gestational age (GA) 20-41 weeks. QT and QTc intervals have been calculated to test the level of agreement between the model-based and reference values (fsECG and Doppler Ultrasound (DUS) signals) in normal subjects. The results of the test showed high agreement between model-based and reference values (difference < 5%), which implies that the proposed model could be an alternative method to detect the end of T waves in nfECG signals. Public Library of Science 2020-05-11 /pmc/articles/PMC7213701/ /pubmed/32392232 http://dx.doi.org/10.1371/journal.pone.0232769 Text en © 2020 Widatalla et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Widatalla, Namareq Kasahara, Yoshiyuki Kimura, Yoshitaka Khandoker, Ahsan Model based estimation of QT intervals in non-invasive fetal ECG signals |
title | Model based estimation of QT intervals in non-invasive fetal ECG signals |
title_full | Model based estimation of QT intervals in non-invasive fetal ECG signals |
title_fullStr | Model based estimation of QT intervals in non-invasive fetal ECG signals |
title_full_unstemmed | Model based estimation of QT intervals in non-invasive fetal ECG signals |
title_short | Model based estimation of QT intervals in non-invasive fetal ECG signals |
title_sort | model based estimation of qt intervals in non-invasive fetal ecg signals |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213701/ https://www.ncbi.nlm.nih.gov/pubmed/32392232 http://dx.doi.org/10.1371/journal.pone.0232769 |
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