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Model based estimation of QT intervals in non-invasive fetal ECG signals

The end timing of T waves in fetal electrocardiogram (fECG) is important for the evaluation of ST and QT intervals which are vital markers to assess cardiac repolarization patterns. Monitoring malignant fetal arrhythmias in utero is fundamental to care in congenital heart anomalies preventing perina...

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Autores principales: Widatalla, Namareq, Kasahara, Yoshiyuki, Kimura, Yoshitaka, Khandoker, Ahsan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213701/
https://www.ncbi.nlm.nih.gov/pubmed/32392232
http://dx.doi.org/10.1371/journal.pone.0232769
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author Widatalla, Namareq
Kasahara, Yoshiyuki
Kimura, Yoshitaka
Khandoker, Ahsan
author_facet Widatalla, Namareq
Kasahara, Yoshiyuki
Kimura, Yoshitaka
Khandoker, Ahsan
author_sort Widatalla, Namareq
collection PubMed
description The end timing of T waves in fetal electrocardiogram (fECG) is important for the evaluation of ST and QT intervals which are vital markers to assess cardiac repolarization patterns. Monitoring malignant fetal arrhythmias in utero is fundamental to care in congenital heart anomalies preventing perinatal death. Currently, reliable detection of end of T waves is possible only by using fetal scalp ECG (fsECG) and fetal magnetocardiography (fMCG). fMCG is expensive and less accessible and fsECG is an invasive technique available only during intrapartum period. Another safer and affordable alternative is the non-invasive fECG (nfECG) which can provide similar assessment provided by fsECG and fMECG but with less accuracy (not beat by beat). Detection of T waves using nfECG is challenging because of their low amplitudes and high noise. In this study, a novel model-based method that estimates the end of T waves in nfECG signals is proposed. The repolarization phase has been modeled as the discharging phase of a capacitor. To test the model, fECG signals were collected from 58 pregnant women (age: (34 ± 6) years old) bearing normal and abnormal fetuses with gestational age (GA) 20-41 weeks. QT and QTc intervals have been calculated to test the level of agreement between the model-based and reference values (fsECG and Doppler Ultrasound (DUS) signals) in normal subjects. The results of the test showed high agreement between model-based and reference values (difference < 5%), which implies that the proposed model could be an alternative method to detect the end of T waves in nfECG signals.
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spelling pubmed-72137012020-05-26 Model based estimation of QT intervals in non-invasive fetal ECG signals Widatalla, Namareq Kasahara, Yoshiyuki Kimura, Yoshitaka Khandoker, Ahsan PLoS One Research Article The end timing of T waves in fetal electrocardiogram (fECG) is important for the evaluation of ST and QT intervals which are vital markers to assess cardiac repolarization patterns. Monitoring malignant fetal arrhythmias in utero is fundamental to care in congenital heart anomalies preventing perinatal death. Currently, reliable detection of end of T waves is possible only by using fetal scalp ECG (fsECG) and fetal magnetocardiography (fMCG). fMCG is expensive and less accessible and fsECG is an invasive technique available only during intrapartum period. Another safer and affordable alternative is the non-invasive fECG (nfECG) which can provide similar assessment provided by fsECG and fMECG but with less accuracy (not beat by beat). Detection of T waves using nfECG is challenging because of their low amplitudes and high noise. In this study, a novel model-based method that estimates the end of T waves in nfECG signals is proposed. The repolarization phase has been modeled as the discharging phase of a capacitor. To test the model, fECG signals were collected from 58 pregnant women (age: (34 ± 6) years old) bearing normal and abnormal fetuses with gestational age (GA) 20-41 weeks. QT and QTc intervals have been calculated to test the level of agreement between the model-based and reference values (fsECG and Doppler Ultrasound (DUS) signals) in normal subjects. The results of the test showed high agreement between model-based and reference values (difference < 5%), which implies that the proposed model could be an alternative method to detect the end of T waves in nfECG signals. Public Library of Science 2020-05-11 /pmc/articles/PMC7213701/ /pubmed/32392232 http://dx.doi.org/10.1371/journal.pone.0232769 Text en © 2020 Widatalla et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Widatalla, Namareq
Kasahara, Yoshiyuki
Kimura, Yoshitaka
Khandoker, Ahsan
Model based estimation of QT intervals in non-invasive fetal ECG signals
title Model based estimation of QT intervals in non-invasive fetal ECG signals
title_full Model based estimation of QT intervals in non-invasive fetal ECG signals
title_fullStr Model based estimation of QT intervals in non-invasive fetal ECG signals
title_full_unstemmed Model based estimation of QT intervals in non-invasive fetal ECG signals
title_short Model based estimation of QT intervals in non-invasive fetal ECG signals
title_sort model based estimation of qt intervals in non-invasive fetal ecg signals
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213701/
https://www.ncbi.nlm.nih.gov/pubmed/32392232
http://dx.doi.org/10.1371/journal.pone.0232769
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