The Role of DLLs in Cancer: A Novel Therapeutic Target

Delta-like ligands (DLLs) control Notch signaling. DLL1, DLL3 and DLL4 are frequently deregulated in cancer and influence tumor growth, the tumor vasculature and tumor immunity, which play different roles in cancer progression. DLLs have attracted intense research interest as anti-cancer therapeutic...

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Detalles Bibliográficos
Autores principales: Xiu, Meng-Xi, Liu, Yuan-Meng, Kuang, Bo-hai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213894/
https://www.ncbi.nlm.nih.gov/pubmed/32440154
http://dx.doi.org/10.2147/OTT.S244860
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author Xiu, Meng-Xi
Liu, Yuan-Meng
Kuang, Bo-hai
author_facet Xiu, Meng-Xi
Liu, Yuan-Meng
Kuang, Bo-hai
author_sort Xiu, Meng-Xi
collection PubMed
description Delta-like ligands (DLLs) control Notch signaling. DLL1, DLL3 and DLL4 are frequently deregulated in cancer and influence tumor growth, the tumor vasculature and tumor immunity, which play different roles in cancer progression. DLLs have attracted intense research interest as anti-cancer therapeutics. In this review, we discuss the role of DLLs in cancer and summarize the emerging DLL-relevant targeting methods to aid future studies.
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spelling pubmed-72138942020-05-21 The Role of DLLs in Cancer: A Novel Therapeutic Target Xiu, Meng-Xi Liu, Yuan-Meng Kuang, Bo-hai Onco Targets Ther Review Delta-like ligands (DLLs) control Notch signaling. DLL1, DLL3 and DLL4 are frequently deregulated in cancer and influence tumor growth, the tumor vasculature and tumor immunity, which play different roles in cancer progression. DLLs have attracted intense research interest as anti-cancer therapeutics. In this review, we discuss the role of DLLs in cancer and summarize the emerging DLL-relevant targeting methods to aid future studies. Dove 2020-05-07 /pmc/articles/PMC7213894/ /pubmed/32440154 http://dx.doi.org/10.2147/OTT.S244860 Text en © 2020 Xiu et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Xiu, Meng-Xi
Liu, Yuan-Meng
Kuang, Bo-hai
The Role of DLLs in Cancer: A Novel Therapeutic Target
title The Role of DLLs in Cancer: A Novel Therapeutic Target
title_full The Role of DLLs in Cancer: A Novel Therapeutic Target
title_fullStr The Role of DLLs in Cancer: A Novel Therapeutic Target
title_full_unstemmed The Role of DLLs in Cancer: A Novel Therapeutic Target
title_short The Role of DLLs in Cancer: A Novel Therapeutic Target
title_sort role of dlls in cancer: a novel therapeutic target
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213894/
https://www.ncbi.nlm.nih.gov/pubmed/32440154
http://dx.doi.org/10.2147/OTT.S244860
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