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The Fully human anti-CD47 antibody SRF231 exerts dual-mechanism antitumor activity via engagement of the activating receptor CD32a

BACKGROUND: CD47 is a broadly expressed cell surface glycoprotein associated with immune evasion. Interaction with the inhibitory receptor signal regulatory protein alpha (SIRPα), primarily expressed on myeloid cells, normally serves to restrict effector function (eg, phagocytosis and immune cell ho...

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Detalles Bibliográficos
Autores principales:	Peluso, Marisa O, Adam, Ammar, Armet, Caroline M, Zhang, Li, O’Connor, Rachel W, Lee, Benjamin H, Lake, Andrew C, Normant, Emmanuel, Chappel, Scott C, Hill, Jonathan A, Palombella, Vito J, Holland, Pamela M, Paterson, Alison M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2020
Materias:	Oncolytic and Local Immunotherapy
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213910/ https://www.ncbi.nlm.nih.gov/pubmed/32345627 http://dx.doi.org/10.1136/jitc-2019-000413

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