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Co-infection with respiratory pathogens among COVID-2019 cases
Accumulating evidence shows that microbial co-infection increases the risk of disease severity in humans. There have been few studies about SARS-CoV-2 co-infection with other pathogens. In this retrospective study, 257 laboratory-confirmed COVID-19 patients in Jiangsu Province were enrolled from Jan...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Published by Elsevier B.V.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213959/ https://www.ncbi.nlm.nih.gov/pubmed/32408156 http://dx.doi.org/10.1016/j.virusres.2020.198005 |
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author | Zhu, Xiaojuan Ge, Yiyue Wu, Tao Zhao, Kangchen Chen, Yin Wu, Bin Zhu, Fengcai Zhu, Baoli Cui, Lunbiao |
author_facet | Zhu, Xiaojuan Ge, Yiyue Wu, Tao Zhao, Kangchen Chen, Yin Wu, Bin Zhu, Fengcai Zhu, Baoli Cui, Lunbiao |
author_sort | Zhu, Xiaojuan |
collection | PubMed |
description | Accumulating evidence shows that microbial co-infection increases the risk of disease severity in humans. There have been few studies about SARS-CoV-2 co-infection with other pathogens. In this retrospective study, 257 laboratory-confirmed COVID-19 patients in Jiangsu Province were enrolled from January 22 to February 2, 2020. They were re-confirmed by real-time RT-PCR and tested for 39 respiratory pathogens. In total, 24 respiratory pathogens were found among the patients, and 242 (94.2 %) patients were co-infected with one or more pathogens. Bacterial co-infections were dominant in all COVID-19 patients, Streptococcus pneumoniae was the most common, followed by Klebsiella pneumoniae and Haemophilus influenzae. The highest and lowest rates of co-infections were found in patients aged 15–44 and below 15, respectively. Most co-infections occurred within 1–4 days of onset of COVID-19 disease. In addition, the proportion of viral co-infections, fungal co-infections and bacterial-fungal co-infections were the highest severe COVID-19 cases. These results will provide a helpful reference for diagnosis and clinical treatment of COVID-19 patients. |
format | Online Article Text |
id | pubmed-7213959 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Published by Elsevier B.V. |
record_format | MEDLINE/PubMed |
spelling | pubmed-72139592020-05-12 Co-infection with respiratory pathogens among COVID-2019 cases Zhu, Xiaojuan Ge, Yiyue Wu, Tao Zhao, Kangchen Chen, Yin Wu, Bin Zhu, Fengcai Zhu, Baoli Cui, Lunbiao Virus Res Article Accumulating evidence shows that microbial co-infection increases the risk of disease severity in humans. There have been few studies about SARS-CoV-2 co-infection with other pathogens. In this retrospective study, 257 laboratory-confirmed COVID-19 patients in Jiangsu Province were enrolled from January 22 to February 2, 2020. They were re-confirmed by real-time RT-PCR and tested for 39 respiratory pathogens. In total, 24 respiratory pathogens were found among the patients, and 242 (94.2 %) patients were co-infected with one or more pathogens. Bacterial co-infections were dominant in all COVID-19 patients, Streptococcus pneumoniae was the most common, followed by Klebsiella pneumoniae and Haemophilus influenzae. The highest and lowest rates of co-infections were found in patients aged 15–44 and below 15, respectively. Most co-infections occurred within 1–4 days of onset of COVID-19 disease. In addition, the proportion of viral co-infections, fungal co-infections and bacterial-fungal co-infections were the highest severe COVID-19 cases. These results will provide a helpful reference for diagnosis and clinical treatment of COVID-19 patients. Published by Elsevier B.V. 2020-08 2020-05-11 /pmc/articles/PMC7213959/ /pubmed/32408156 http://dx.doi.org/10.1016/j.virusres.2020.198005 Text en © 2020 Published by Elsevier B.V. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Zhu, Xiaojuan Ge, Yiyue Wu, Tao Zhao, Kangchen Chen, Yin Wu, Bin Zhu, Fengcai Zhu, Baoli Cui, Lunbiao Co-infection with respiratory pathogens among COVID-2019 cases |
title | Co-infection with respiratory pathogens among COVID-2019 cases |
title_full | Co-infection with respiratory pathogens among COVID-2019 cases |
title_fullStr | Co-infection with respiratory pathogens among COVID-2019 cases |
title_full_unstemmed | Co-infection with respiratory pathogens among COVID-2019 cases |
title_short | Co-infection with respiratory pathogens among COVID-2019 cases |
title_sort | co-infection with respiratory pathogens among covid-2019 cases |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213959/ https://www.ncbi.nlm.nih.gov/pubmed/32408156 http://dx.doi.org/10.1016/j.virusres.2020.198005 |
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