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Co-infection with respiratory pathogens among COVID-2019 cases

Accumulating evidence shows that microbial co-infection increases the risk of disease severity in humans. There have been few studies about SARS-CoV-2 co-infection with other pathogens. In this retrospective study, 257 laboratory-confirmed COVID-19 patients in Jiangsu Province were enrolled from Jan...

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Autores principales: Zhu, Xiaojuan, Ge, Yiyue, Wu, Tao, Zhao, Kangchen, Chen, Yin, Wu, Bin, Zhu, Fengcai, Zhu, Baoli, Cui, Lunbiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier B.V. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213959/
https://www.ncbi.nlm.nih.gov/pubmed/32408156
http://dx.doi.org/10.1016/j.virusres.2020.198005
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author Zhu, Xiaojuan
Ge, Yiyue
Wu, Tao
Zhao, Kangchen
Chen, Yin
Wu, Bin
Zhu, Fengcai
Zhu, Baoli
Cui, Lunbiao
author_facet Zhu, Xiaojuan
Ge, Yiyue
Wu, Tao
Zhao, Kangchen
Chen, Yin
Wu, Bin
Zhu, Fengcai
Zhu, Baoli
Cui, Lunbiao
author_sort Zhu, Xiaojuan
collection PubMed
description Accumulating evidence shows that microbial co-infection increases the risk of disease severity in humans. There have been few studies about SARS-CoV-2 co-infection with other pathogens. In this retrospective study, 257 laboratory-confirmed COVID-19 patients in Jiangsu Province were enrolled from January 22 to February 2, 2020. They were re-confirmed by real-time RT-PCR and tested for 39 respiratory pathogens. In total, 24 respiratory pathogens were found among the patients, and 242 (94.2 %) patients were co-infected with one or more pathogens. Bacterial co-infections were dominant in all COVID-19 patients, Streptococcus pneumoniae was the most common, followed by Klebsiella pneumoniae and Haemophilus influenzae. The highest and lowest rates of co-infections were found in patients aged 15–44 and below 15, respectively. Most co-infections occurred within 1–4 days of onset of COVID-19 disease. In addition, the proportion of viral co-infections, fungal co-infections and bacterial-fungal co-infections were the highest severe COVID-19 cases. These results will provide a helpful reference for diagnosis and clinical treatment of COVID-19 patients.
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spelling pubmed-72139592020-05-12 Co-infection with respiratory pathogens among COVID-2019 cases Zhu, Xiaojuan Ge, Yiyue Wu, Tao Zhao, Kangchen Chen, Yin Wu, Bin Zhu, Fengcai Zhu, Baoli Cui, Lunbiao Virus Res Article Accumulating evidence shows that microbial co-infection increases the risk of disease severity in humans. There have been few studies about SARS-CoV-2 co-infection with other pathogens. In this retrospective study, 257 laboratory-confirmed COVID-19 patients in Jiangsu Province were enrolled from January 22 to February 2, 2020. They were re-confirmed by real-time RT-PCR and tested for 39 respiratory pathogens. In total, 24 respiratory pathogens were found among the patients, and 242 (94.2 %) patients were co-infected with one or more pathogens. Bacterial co-infections were dominant in all COVID-19 patients, Streptococcus pneumoniae was the most common, followed by Klebsiella pneumoniae and Haemophilus influenzae. The highest and lowest rates of co-infections were found in patients aged 15–44 and below 15, respectively. Most co-infections occurred within 1–4 days of onset of COVID-19 disease. In addition, the proportion of viral co-infections, fungal co-infections and bacterial-fungal co-infections were the highest severe COVID-19 cases. These results will provide a helpful reference for diagnosis and clinical treatment of COVID-19 patients. Published by Elsevier B.V. 2020-08 2020-05-11 /pmc/articles/PMC7213959/ /pubmed/32408156 http://dx.doi.org/10.1016/j.virusres.2020.198005 Text en © 2020 Published by Elsevier B.V. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Zhu, Xiaojuan
Ge, Yiyue
Wu, Tao
Zhao, Kangchen
Chen, Yin
Wu, Bin
Zhu, Fengcai
Zhu, Baoli
Cui, Lunbiao
Co-infection with respiratory pathogens among COVID-2019 cases
title Co-infection with respiratory pathogens among COVID-2019 cases
title_full Co-infection with respiratory pathogens among COVID-2019 cases
title_fullStr Co-infection with respiratory pathogens among COVID-2019 cases
title_full_unstemmed Co-infection with respiratory pathogens among COVID-2019 cases
title_short Co-infection with respiratory pathogens among COVID-2019 cases
title_sort co-infection with respiratory pathogens among covid-2019 cases
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213959/
https://www.ncbi.nlm.nih.gov/pubmed/32408156
http://dx.doi.org/10.1016/j.virusres.2020.198005
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